实用肝脏病杂志2025，Vol.28Issue(5)：703-706,4.DOI:10.3969/j.issn.1672-5069.2025.05.016
磁共振成像质子密度脂肪分数评估非酒精性脂肪性肝病患者肝脏脂肪变性临床价值研究
Verification of magnetic resonance imaging proton density fat fraction in predicting liver steatosis in patients with nonalcoholic fatty liver disease
摘要
Abstract
Objective The aim of this study was to investigate magnetic resonance imaging proton density fat fraction(MRI-PDFF)in predicting liver steatosis in patients with nonalcoholic fatty liver disease(NAFLD).Methods 96 patients with NAFLD and 55 healthy volunteers were enrolled in our hospital between December 2022 and December 2023,and all underwent MRI scan for MRI-PDFF measurement.Liver stiffness measurement(LSM)AND controlled attenuation parameter(CAP)were detected by transient elastography.Liver biopsy was performed in patients with NAFLD.Results MRI-PDFF,CAPand LSM in patients with NAFLD were(27.5±9.6)％,(297.2±35.2)dB/m and(10.3±2.3)kPa,all significantly higher than[(9.8±3.3)％,(251.7±14.4)dB/m and(5.1±1.3)kPa,respectively,P＜0.05]in healthy persons;LSM,CAPand MRI-PDFF in 16 patients with histology-proven severe liver steatosis were(11.8±2.0)kPa,(341.1±32.2)dB/m and(37.3±8.3)％,all significantly higher than[(10.4±1.8)kPa,(284.0±12.7)dB/m and(25.1±3.4)％,respectively,P＜0.05]in 29 patients with moderate liver steatosis or[(8.9±1.7)kPa,(263.5±7.7)dB/m and(14.4±3.2)％,respectively,P＜0.05]in 51 patients with mild liver steatosis;ROC analysis showed that the AUC was 0.903,with sensitivity of 87.5％and specificity of 93.1％(P＜0.05),when MRI-PDFF equal to or greater than 31.4％was set as the cut-off-value in predicting severe liver steatosis in patients with NAFLD.Conclusion Utility of MRI-PDFF could help clinicians for surveillance of liver steatosis in patients with NAFLD in clinical practice,especially for dynamic evaluation in process of intervention.关键词
非酒精性脂肪性肝病/肝脂肪变性/磁共振成像质子密度脂肪分数/诊断Key words
Nonalcoholic fatty liver disease/Liver steatosis/Magnetic resonance imaging proton density fat fraction/Diagnosis引用本文复制引用
葛天明,吴启源,于小伟,李冠武..磁共振成像质子密度脂肪分数评估非酒精性脂肪性肝病患者肝脏脂肪变性临床价值研究[J].实用肝脏病杂志,2025,28(5):703-706,4.基金项目
上海市中医优势病种培育项目(编号:zybz-2017054) （编号:zybz-2017054）
