实用肝脏病杂志2025，Vol.28Issue(5)：715-718,4.DOI:10.3969/j.issn.1672-5069.2025.05.019
艾塞那肽联合多烯磷脂酰胆碱治疗酒精性肝炎患者初步疗效研究
Application of exenatide at base of oral polyenephosphatidylcholine in treatment of patients with alcoholic hepatitis
摘要
Abstract
Objective The aim of this study was to investigate therapeutic efficacy of exenatideplus oralpolyenephosphatidylcholine in the treatment of patients with alcoholic hepatitis(AH).Method A total of 102 patients with AH were recruited in our hospital between January 2022 and January 2024,and were randomly assigned to receive oral polyene phosphatidylcholine in 50 patients in control,or receive subcutaneous exenatide injection plus oral polyene phosphatidylcholine in 52 patients in combination group for three months.Serum hyaluronic acid(HA),type Ⅲ procollagen(PC-Ⅲ),collagen fiber Ⅳ(ⅳ-C)and laminin(LN))levels were detected by radioimmunoassay,and serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and IL-8 levels were assayed by ELISA.Result By end of three month treatment,serum ALT,AST,GGT and total bilirubin levels in combination groupwere(48.9±15.2)U/L,(45.6±12.5)U/L,(119.5±30.6)U/L and(23.1±5.6)μmol/L,all significantly lower than[(69.3±20.1)U/L,(79.6±18.1)U/L,(168.8±50.7)U/Land(33.5±6.9)μmol/L,respectively,P＜0.05]in the control;serum HA,PC-Ⅲ,Ⅳ-C and LN levels in the combination group were(128.5±20.3)μg/L,(132.3±29.1)μg/L,(41.2±9.1)mg/mL and(105.4±20.6)mg/mL,all significantly lower than[(152.2±22.1)μg/L,(186.5±30.4)μg/L,(57.3±10.2)mg/mL and(134.5±20.1)mg/mL,respectively,P＜0.05]in the control group;serum TNF-α,IL-6 and IL-8 levels in the combination group were(236.1±100.8)pg/L,(35.1±10.8)pg/L and(10.5±3.8)ng/L,all much lower than[(286.7±105.6)pg/L,(50.1±11.4)pg/L and(17.1±4.5)ng/L,respectively,P＜0.05]in the control group;there was no significant difference in the incidence of adverse reactions between the two groups(13.5％vs.10.0％,P＞0.05).Conclusion Additional injection of exenatideat basis of oral polyenephosphatidylcholine therapy could improve liver function normal in patients with alcoholic hepatitis,which might be related to inhibition of body inflammatory reactions.关键词
酒精性肝炎/艾塞那肽/多烯磷脂酰胆碱/治疗Key words
Alcoholic hepatitis/Exenatide/Polyenephosphatidylcholine/Therapy引用本文复制引用
王霞,段旺旺,李梦辉..艾塞那肽联合多烯磷脂酰胆碱治疗酒精性肝炎患者初步疗效研究[J].实用肝脏病杂志,2025,28(5):715-718,4.基金项目
陕西省重点研发计划项目(编号:2020SF-217) （编号:2020SF-217）
