Abstract
Objective The aim of this study was to summarize clinical feature of patients with IgG4-related sclerosing cholangitis(IgG4-SC)and concomitant autoimmune pancreatitis(AIP).Methods 28 patients with AIP and 19 patients with AIP and concomitant IgG4-SC were encountered in our hospital between November 2020 and April 2023,and all underwent liver biopsies and abdominal CT scan.Serum IgG and IgG4 levels were detected by ELISA,and IgG4-RD activity responder index(RI)were calculated.Patients were treated by prednisone and/or ursodeoxycholic acid(UDCA).Results Percentage of concomitant diabetes,involved organ and RI in patients with AIP and IgG4-SC were 68.4％,3.0(2.5,4.5)and 12.5(12.0,14.5),all significant higher than[35.7％,2.0(1.0,2.5)and 7.0(5.0,8.0),respectively,P＜0.05]in patients with AIP;incidence of abdominal pain in patients with AIP and IgG4-SC was 73.7％,much higher than 42.9％(P＜0.05)in patients with AIP;serum GGT,ALP,IgG,amylase and lipase levels in patients with AIP and IgG4-SC were 574.7(76.8,965.2)U/L,438.0(274.4,638.7)U/L,141.6(134.7,208.5)g/L,38.5(29.7,79.2)U/L and 49.3(36.1,108.5)U/L,all much higher than[298.8(37.5,685.3)U/L,168.5(109.4,374.3)U/L,45.3(30.5,69.4)g/L,16.6(10.6,28.0)U/L and 14.5(8.5,25.8)U/L,respectively,P＜0.05]in patients with AIP;percentages of diffuse pancreatic enlargement,pancreatic stones or calcification and intrahepatic bile duct wall thickening in patients with AIP and IgG4-SC were 78.9％,15.8％and 15.8％,all much higher than 46.4％,3.6％and 3.6％(P＜0.05)in patients with AIP.Conclusion Autoimmune pancreatitis and concomitant IgG4-SC might be clinically sophisticated,and clinicians should assess the disease carefully.We recommend prednisone and UDCA treatment for them.关键词
IgG4相关硬化性胆管炎/自身免疫性胰腺炎/临床特征/预后Key words
IgG4-related sclerosing cholangitis/Autoimmune pancreatitis/Clinical feature/Prognosis
