上海预防医学2025，Vol.37Issue(7)：562-568,7.DOI:10.19428/j.cnki.sjpm.2025.24813
上海市松江区社区自然人群血脂水平与缺血性脑卒中复发风险的队列研究
A cohort study of lipid levels and recurrence risk of ischemic stroke in a community-based natural population in Songjiang District,Shanghai
摘要
Abstract
[Objective]To investigate the recurrence of ischemic stroke(IS)and to analyze the association between four indices of total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),and triglycerides(TG)and the risk of IS recurrence by analyzing the follow-up data related to IS in the community-based natural population of Songjiang District,Shanghai,so as to provide a scientific basis for improving the prognosis of stroke patients in the community and controlling IS recurrence.[Methods]A prospective follow-up study was conducted among the IS patients in the community-based cohort population,collecting data about patient's age,gender,disease history,biochemical indicators,and etc.Cox regression model and restricted cubic spline model were used to analyze the relationship between different levels of plasma lipids and the recurrence of IS in these patients.[Results]A total of 1 368 patients with IS were included.The total follow-up duration was 7 171.46 person-years,with a median follow-up time of 6.24 years.There were 420 cases of IS recurrence,resulting in a cumulative recurrence rate of 30.70％.The results of multivariate Cox regression analysis showed that the recurrence risk of IS was reduced when the baseline TC and LDL-C levels of IS patients were in the ranges of 4.65-5.67 mmol·L-1 and 2.52-3.46 mmol·L-1,respectively.The results of restricted cubic spline analysis showed a U-shaped relationship between baseline TC and LDL-C levels and the recurrence risk in IS patients.[Conclusion]The cumulative recurrence rate of patients with IS in the community of Songjiang District in Shanghai is high,and the levels of TC and LDL-C at baseline survey are correlated with the recurrence of IS in these patients.It is suggested to pay more attention to the levels of LDL-C and TC in patients with IS,so as to improve the prognosis.关键词
社区/队列研究/缺血性脑卒中/血脂/复发Key words
community/cohort study/ischemic stroke/plasma lipid/recurrence分类
医药卫生引用本文复制引用
耿扬博,赵根明,姜永根,金燕,费华圆,阚云龙,唐敏华,王云辉,郁建国,李咏梅,徐解东,吴毅凌..上海市松江区社区自然人群血脂水平与缺血性脑卒中复发风险的队列研究[J].上海预防医学,2025,37(7):562-568,7.基金项目
国家重点研发计划精准医学重点专项(2017YFC0907000) （2017YFC0907000）
上海市加强公共卫生体系建设三年行动计划(2023-2025年)重点学科(GWVI-11.1-23) （2023-2025年）
松江区科技攻关项目(医药卫生类)(2024SJKJGG027) （医药卫生类）
复旦-嘉定公共卫生高质量发展重点学科(GWGZLXK-2023-02) （GWGZLXK-2023-02）
