实用医学杂志2025，Vol.41Issue(18)：2945-2952,8.DOI:10.3969/j.issn.1006-5725.2025.18.023
中药调控小胶质细胞改善卒中后抑郁的研究进展
Modulation of microglia by traditional Chinese medicine improves post-stroke depression
摘要
Abstract
Post-stroke depression(PSD),a common stroke complication characterized by depressed mood and diminished interest,severely affects patients'recovery and quality of life.Microglial abnormal activation and polarization play key roles in PSD pathogenesis,closely associated with neuroinflammation and imbalance in neu-rotransmitter metabolism.In contrast,traditional Chinese medicine(TCM)demonstrates unique multi-target and multi-level mechanisms:regulating microglial function,ameliorating post-stroke neuroinflammatory environments,and promoting neuroplasticity,thereby potentially alleviating PSD symptoms.This review summarizes TCM's effects on microglial activation/polarization states and its therapeutic advances in PSD,providing novel perspectives and strategies for clinical management.关键词
卒中后抑郁/小胶质细胞/中药/调控机制Key words
post-stroke depression/microglia/traditional Chinese medicine/regulatory mechanisms分类
医药卫生引用本文复制引用
李琪,高静,张铭,张栩,冯雅琛,潘蕊,王春晓,任琼迪..中药调控小胶质细胞改善卒中后抑郁的研究进展[J].实用医学杂志,2025,41(18):2945-2952,8.基金项目
国家自然科学基金青年基金资助项目(编号:82104973) （编号:82104973）
河南省中医药科学研究专项(编号:20-21ZY1017) （编号:20-21ZY1017）
河南省中医药传承与创新人才工程(仲景工程)-拔尖人才(编号:CZ0325-14) （仲景工程）
河南省中医学"双一流"创建科学研究专项(编号:HSRP-DFCTCM-2023-3-11) （编号:HSRP-DFCTCM-2023-3-11）
