实用医学杂志2025，Vol.41Issue(18)：2953-2960,8.DOI:10.3969/j.issn.1006-5725.2025.18.024
强直性脊柱炎中Th17细胞分化调控机制及其治疗靶点的研究进展
Research progress on Th17 cell differentiation regulation mechanisms and therapeutic targets in ankylosing spondylitis
摘要
Abstract
Ankylosing spondylitis(AS)is a chronic autoimmune disease characterized by inflammatory involvement of the axial skeleton and pathological bone formation.The T helper 17 cell(Th17 cell)subset of lym-phocytes plays a central role in mediating the inflammatory processes associated with AS.This review summarizes recent advances in the regulation of Th17 cell differentiation in AS,with a focus on the complex mechanisms governed by cytokine microenvironments,transcription factor networks,and metabolic and epigenetic regulatory pathways.Key regulatory components discussed include the IL-23/STAT3 signaling axis,the CCL20/CCR6 chemo-tactic axis,and the master transcription factor RORγt.Additionally,this review critically evaluates emerging thera-peutic strategies targeting metabolic reprogramming(e.g.,PKM2),epigenetic regulators(e.g.,JMJD3,EZH2),engineered exosome delivery systems,and modulators of metabolic enzymes.By analyzing the limitations of current treatment approaches,the review proposes future research directions emphasizing multi-target therapeutic strategies and highlights the importance of personalized medicine in achieving precise and effective treatment for AS.These developments reveal promising new avenues for modulating Th17-mediated immunity,offering transformative poten-tial for the clinical management of AS.关键词
强直性脊柱炎/Th17细胞/IL-17/IL-23轴/信号通路/靶向治疗/转录调控/骨重塑Key words
ankylosing spondylitis/Th17 cells/IL-23/IL-17 axis/signaling pathways/targeted therapy/transcriptional regulation/bone remodeling分类
医药卫生引用本文复制引用
余明阳,李甲,冯新哲,毕晶晶,李诚..强直性脊柱炎中Th17细胞分化调控机制及其治疗靶点的研究进展[J].实用医学杂志,2025,41(18):2953-2960,8.基金项目
国家自然科学基金项目(编号:82402766) （编号:82402766）
海军军医大学第一附属医院"长风破浪·海纳百川"人才工程基金项目 （）
