生命科学研究2025，Vol.29Issue(4)：297-303,7.DOI:10.16605/j.cnki.1007-7847.2024.12.0205
多胺调控动物机体昼夜节律与炎症损伤机制的研究进展
Research Progress on Regulatory Mechanisms of Polyamines in Animal Circadian Rhythm and Inflammatory Injury
摘要
Abstract
Polyamines are essential for normal physiological regulation in animals.Recent research reveals the dual role of polyamines in both modulating animal circadian rhythms and mediating inflammatory re-sponses and recovery.While cellular polyamine levels are typically maintained at low concentrations,excess accumulation can adversely affect circadian regulation and inflammatory responses in animals.At the mole-cular level,polyamines function through directly participating in transcriptional-translational feedback loop and modulating the expression of key inflammatory mediators.This review summarizes current advances in the roles of polyamines in circadian rhythm regulation and inflammatory responses from perspectives of polyamine levels and molecular mechanisms,outlines several underlying mechanisms,and discusses future research priorities.关键词
多胺/鸟氨酸脱羧酶(ODC)/节律蛋白质/炎症因子/昼夜节律/炎症损伤Key words
polyamine/ornithine decarboxylase(ODC)/circadian protein/inflammatory factor/circadian rhy-thm/inflammatory injury分类
生物科学引用本文复制引用
林佳琪,甄永康,张冲,钟宇虹,马建军,王梦芝..多胺调控动物机体昼夜节律与炎症损伤机制的研究进展[J].生命科学研究,2025,29(4):297-303,7.基金项目
科技部"十四五"国家重点研发专项(2024YFD1300204,2023YFD1301705) （2024YFD1300204,2023YFD1301705）
新疆生产建设兵团农业科技创新工程专项(NCG202232) （NCG202232）
