生命科学研究2025，Vol.29Issue(4)：350-363,376,15.DOI:10.16605/j.cnki.1007-7847.2025.01.0113
2019冠状病毒病与多发性硬化的趋同分子景观:中性粒细胞浸润及S100A8轴(英文)
Convergent Molecular Landscapes of COVID-19 and Multiple Sclerosis:Neutrophil Infiltration and the S100A8 Axis(English)
摘要
Abstract
Despite suggested shared pathophysiological mechanisms between coronavirus disease 2019(COVID-19)and multiple sclerosis(MS),the molecular pathways underlying their relationship remain unclear.Herein,gene expression profiles of COVID-19(GSE171110,GSE152641)and MS(GSE66573,GSE159225)datasets were analyzed using Gene Ontology(GO)enrichment analysis,Kyoto Encyclopedia of Genes and Ge-nomes(KEGG)pathway enrichment analysis,and protein-protein interaction(PPI)network construction.A two-sample Mendelian randomization(MR)study was performed to establish potential causal relationships.A to-tal of 165 shared differentially expressed genes(DEGs)were identified,with significant enrichment in path-ways related to humoral immune response,neutrophil migration,and cytokine-receptor interactions in both conditions.Validation by receiver operating characteristic(ROC)curve analysis demonstrated that the hub genes S100A8,S100A9,S100A12,and ALOX5AP achieved area under the curve(AUC)values above 0.7 for both diseases.Increased neutrophil infiltration was positively correlated with upregulated expression of these genes,particularly demonstrating significant associations between the hub gene expression and neutrophil activity pathways.MR analysis suggested a causal relationship betweenS100A 8 expression and susceptibility to both conditions and neutrophil counts,while ALOX5AP was indicated as a potential MS risk factor.These findings suggest that COVID-19 and MS co-occurrence is associated with neutrophil infiltration,highligh-ting SS100A 8 as both a promising biomarker and therapeutic target.关键词
2019冠状病毒病(COVID-19)/多发性硬化(MS)/中性粒细胞/免疫过程/多组学/孟德尔随机化Key words
coronavirus disease 2019(COVID-19)/multiple sclerosis(MS)/neutrophil/immune process/multi-omics/Mendelian randomization(MR)分类
生物科学引用本文复制引用
麻可强,蔡逸声,黄少彬,蔡雅煊,杜鸿,曾勇,谭丽君,屈晓超,陈湘定..2019冠状病毒病与多发性硬化的趋同分子景观:中性粒细胞浸润及S100A8轴(英文)[J].生命科学研究,2025,29(4):350-363,376,15.基金项目
湖南省大学生研究性学习和创新性实验计划项目(S202410542120) Hunan Province College Students Research Learning and Innovative Experiment Project(S202410542120) （S202410542120）
