天津中医药2025，Vol.42Issue(9)：1106-1110,5.DOI:10.11656/j.issn.1672-1519.2025.09.04
醒脑开窍针刺联合通窍活血汤对脑卒中后癫痫患者脑血流动力学指标及氧化应激指标的影响
Effect of Xingnao Kaiqiao acupuncture combined with Tongqiao Huoxue Decoction on cerebral hemodynamic and oxidative stress indicators in post-stroke epilepsy patients
摘要
Abstract
[Objective]To investigate the effects of Xingnao Kaiqiao acupuncture combined with Tongqiao Huoxue Decoction on cerebral hemodynamics and oxidative stress indicators in patients with post-stroke epilepsy(EP).[Methods]A total of 80 post-stroke EP patients admitted to Qingyang Traditional Chinese Medicine Hospital from May 2021 to January 2024 were randomly divided into control group(40 cases)and observation group(40 cases).The control group was treated with conventional Western medicine,while the observation group received additional Xingnao Kaiqiao acupuncture and Tongqiao Huoxue Decoction for 2 months.Efficacy was compared between the two groups.EP episodes,oxidative stress index[malondialdehyde(MDA),nitric oxide synthase(NOS),superoxide dismutase(SOD)],cerebral hemodynamic index[mean blood flow velocity(Vm)of bilateral middle cerebral artery(MCA),maximum peak flow velocity(Vs),pressure index(PA),resistance index(RI)]were compared before and after treatment.Adverse reactions were recorded.[Results]The total effective rate was significantly higher in the observation group(95.00％)than in the control group(77.50％,P＜0.05).After treatment,the observation group had fewer EP episodes shorter than the control group(P＜0.05),and MDA levels in the two groups changed more significantly(P＜0.05).After treatment,the Vm and Vs values of bilateral MAC in both groups increased,the PA value decreased,and the observation group changed more significantly(P＜0.05).No significant difference in adverse reactions was observed(P＞0.05).[Conclusion]Xingnao Kaiqiao acupuncture combined with Tongqiao Huoxue Decoction can improve therapeutic efficacy,alleviate oxidative stress,enhance cerebral hemodynamics,and reduce seizure severity in post-stroke EP patients.关键词
脑卒中/癫痫/针刺/通窍活血汤/脑血流动力学/氧化应激Key words
stroke/epilepsy/acupuncture/Tongqiao Huoxue Decoction/cerebral hemodynamics/oxidative stress分类
医药卫生引用本文复制引用
范乾,张苗苗,殷宝..醒脑开窍针刺联合通窍活血汤对脑卒中后癫痫患者脑血流动力学指标及氧化应激指标的影响[J].天津中医药,2025,42(9):1106-1110,5.基金项目
2022年度甘肃省中医药科研项目(GZKG-2022-55) （GZKG-2022-55）
2022年度第二批市级科技计划自筹经费项目(QY-STK-2022B-090). （QY-STK-2022B-090）
