实用医学杂志2025，Vol.41Issue(18)：2806-2811,6.DOI:10.3969/j.issn.1006-5725.2025.18.004
黏弹性成像联合剪切波弹性成像在乳腺癌诊断中的价值评估
Evaluation of the diagnostic value of sound touch viscoelastography combined with shear wave elastography in breast cancer diagnosis
摘要
Abstract
Objective To evaluate the diagnostic efficacy of sound touch viscoelastography(STVi)and shear wave elastography(SWE)in distinguishing between benign and malignant breast nodules.Methods A total of 104 breast nodules(52 benign and 52 malignant)from 102 patients scheduled for surgical treatment at Binzhou Medical University Hospital between October 2024 and February 2025 were prospectively enrolled.All nodules were pathologically confirmed through surgical excision or core needle biopsy.The viscosity coefficient and Young's modulus of both intranodular and perinodular tissues within a 2-mm range were measured using the Mindray Resona A20S ultrasound system.The diagnostic performance of each parameter,the correlation between elastic parameter values and the maximum nodule diameter,as well as the inter-correlation between the two parameters were systematically analyzed.Results The elasticity parameters were significantly higher in malignant nodules[maximum intranodular Viscosity coefficient(Vimax):5.93(4.33,8.47)Pa·s,maximum Young's modulus(Emax):81.18(58.31,120.33)kPa;maximum Viscosity coefficient of the surrounding 2-mm tissue(Vi2max):7.57(5.40,10.16)Pa·s,maximum Young's modulus(E2max):117.21(65.66,170.66)kPa]compared to benign nodules[Vimax:3.70(2.69,5.32)Pa·s,Emax:41.42(28.29,64.25)kPa;Vi2max:4.30(3.63,5.65)Pa·s,E2max:47.23(36.42,74.67)kPa](P<0.05).The diagnostic performance of the 2-mm perinodular tissue(Vi2max:0.78,E2max:0.81)surpassed that of intranodular tissue(Vimax:0.72,Emax:0.77)(P<0.05).The combined diagnostic model(Vi2+E2,Vi+E)achieved AUC values of 0.82 and 0.77,respectively,which outperformed STVi alone(P<0.05)and showed marginally better performance than SWE alone,although the difference was not statistically significant(P>0.05).The maximum nodule diameter showed a moderate correlation with the elasticity parameters,with E2max exhibiting the strongest correlation(r=0.510,P<0.05).Conclusions Both STVi and SWE show clinical value in distinguishing between benign and malignant breast nodules.Particularly,elasticity parameters obtained from the 2-mm perinodular tissue demonstrate better diagnostic performance than those measured within the nodule itself,and combining these parameters enhances the overall diagnostic accuracy of STVi.关键词
乳腺结节/黏弹性成像/剪切波弹性成像/良恶性鉴别/结节最大径Key words
breast nodules/sound touch viscoelastography/shear wave elastography/benign-malignant differentiation/maximum diameter of the nodule分类
医药卫生引用本文复制引用
刘钊,李慧,王敏敏,王坤,刘菲菲,王玉华,张文晓..黏弹性成像联合剪切波弹性成像在乳腺癌诊断中的价值评估[J].实用医学杂志,2025,41(18):2806-2811,6.基金项目
山东省自然科学基金项目(编号:ZR2023QH231) （编号:ZR2023QH231）
山东省医药卫生科技发展计划项目(编号:202109021017,202409021312) （编号:202109021017,202409021312）
