西安交通大学学报（医学版）2025，Vol.46Issue(5)：763-768,6.DOI:10.7652/jdyxb202505007
身体质量指数与认知障碍的年龄依赖性关系:一项以西安市40岁及以上农村人群为基础的横断面研究
Age-dependent relationship between body mass index and cognitive impairment:a cross-sectional study based on the rural population aged 40 years and above in Xi'an,China
摘要
Abstract
Objective To study the age-dependent relationship between body mass index(BMI)and cognitive impairment in rural population aged 40 years and above.Methods From October 2014 to March 2015,people aged 40 years and above,who lived in two natural villages in Huyi District of Xi'an,were selected as the research subjects.Their general demographic information,lifestyle,medical history,family history,physical examination,and biochemical examination were collected.Mini-Mental State Examination(MMSE)was used to evaluate global cognitive function.Cognitive impairment was defined as an MMSE score lower than the cutoff value,specifically,scores ≤17 for subjects who were illiterate,scores ≤20 for subjects with primary school education,and scores ≤24 for subjects with junior high school education or above.The age-dependent relationship between BMI and cognitive impairment was discussed using stratified analysis,restricted cubic spline(RCS),and multivariate Logistic regression.Results We included a total of 1 792 subjects in the analysis,of whom 230(12.8％)were diagnosed with cognitive impairment.There were 726 males(40.5％);the average age was(55.53±9.92)years,ranging from 40 to 85 years,1 193 subjects aged 40-59 years(66.6％),and 599 subjects aged ≥60 years(33.4％).The average BMI was(25.29±3.14)kg/m2.In the total population,BMI index was fitted as restricted cubic splines in the Logistic regression model,and other confounding factors were corrected.The results showed that BMI index was significantly correlated with cognitive impairment(Poverall=0.023),and there was a trend of nonlinear relationship(P nonlinear=0.097).The specific relationship was that with BMI=25 kg/m2 as the reference(OR=1),when BMI index was＜25 kg/m2,the OR value increased as BMI index decreased.However,when BMI index was ≥25 kg/m2,the OR value did not change significantly as BMI index increased.The population was divided into two subgroups according to age(40-59 years vs.≥60 years).Stratified analysis showed that in the ≥60 years old subgroup,cognitive impairment had significant correlation with BMI index(Poverall=0.038,Pnonlinear=0.097),and the changing trend of the correlation was similar to that of the overall population.By contrast,in the 40-59 years old subgroup,BMI index was not significantly associated with cognitive impairment(Poverall=0.722,Pnonlinear=0.738).Conclusion The relationship between BMI and cognitive impairment is affected by age.No significant association is found in the middle-aged population of 40-59 years old,but there may be a nonlinear association in the elderly population over 60 years old.Specifically,with BMI=25 kg/m2 as the boundary,as BMI decreases,the risk of cognitive impairment gradually increases.As BMI further increases,the risk of cognitive impairment does not change significantly even though it reaches the obesity level.关键词
认知障碍/危险因素/身体质量指数/年龄/横断面研究Key words
cognitive impairment/risk factor/age/body mass index/cross-sectional study分类
医药卫生引用本文复制引用
崔思萌,刘子钰,党亮君,江毓,王敬谊,米白冰,屈秋民,商苏杭..身体质量指数与认知障碍的年龄依赖性关系:一项以西安市40岁及以上农村人群为基础的横断面研究[J].西安交通大学学报（医学版）,2025,46(5):763-768,6.基金项目
科技创新-2030重大项目(No.2021ZD0201808) （No.2021ZD0201808）
国家自然科学基金资助项目(No.82301364,No.82201580)Supported by the STI2030-Major Project(2021ZD0201808)and the National Natural Science Foundation of China(No.82301364,No.82201580) （No.82301364,No.82201580）
