西安交通大学学报（医学版）2025，Vol.46Issue(5)：769-774,6.DOI:10.7652/jdyxb202505008
吸烟与认知功能下降的关系:西安农村人群4年前瞻性队列研究
Relationship between smoking and cognitive decline:a 4-year cohort prospective study on rural population in Xi'an
摘要
Abstract
Objective This study examined the association between smoking and cognitive decline through a cohort in rural population in Xi'an.Methods Data were collected from the cognitive impairment cohort of middle-aged and elderly people in rural areas of Xi'an.The cohort selected the population aged 40 years and above in rural Xi'an.The baseline survey was completed between October 2014 and March 2015,and two follow-up visits were conducted in 2016 and 2018.This study took the baseline cognitively normal population of this cohort as the research subjects.According to the survey results in 2018,the population was divided into three groups according to smoking status:smoking,quitting and non-smoking.Cognitive function was assessed by Mini-Mental State Examination(MMSE).△MMSE(2014 rating-2018 rating)≥2 was defined as cognitive decline,and △MMSE＜2 was defined as cognitive stability.Binary Logistic regression model and stratified analysis were used to analyze the relationship between smoking and cognitive decline and the influence of age on the relationship.Results A total of 1 289 subjects were included in this study.According to smoking status in 2018,they were divided into non-smokers(910,70.6％),smokers(335,26.0％),and ex-smokers(44,3.4％).In the total population,there was no significant difference in the incidence of cognitive decline among non-smokers,smokers and ex-smokers(17.3％vs.16.1％vs.15.9％,P=0.880).When stratified by age,there was no significant difference in the incidence of cognitive decline among the three groups in the subgroup of age＜65 years(16.5％vs.13.2％vs.12.1％,P=0.365).In the subgroup of age≥65 years,no significant difference was found in the incidence of cognitive decline among non-smokers,smokers and ex-smokers(20.8％vs.30.9％vs.27.3％,P=0.306).After adjusting for confounding factors,smokers had a significantly higher risk of cognitive decline than non-smokers(OR=14.139;95％CI:1.541-129.705;P=0.019).There was a trend of cognitive decline in the ex-smokers group,but with no statistical significance(OR=8.252;95％CI:0.630-108.175;P=0.108).Conclusion Smoking is positively associated with cognitive decline in the elderly,suggesting that smoking may accelerate cognitive decline in this population.关键词
认知功能下降/危险因素/吸烟/队列研究Key words
cognitive decline/risk factor/smoking/cohort study分类
医药卫生引用本文复制引用
刘洁,王子晗,郭晓娟,商苏杭,陈晨,王敬谊,屈秋民,王瑾..吸烟与认知功能下降的关系:西安农村人群4年前瞻性队列研究[J].西安交通大学学报（医学版）,2025,46(5):769-774,6.基金项目
国家科技部科技创新2030-"脑科学与类脑研究"重大项目(No.2021ZD0201808) （No.2021ZD0201808）
国家自然科学基金青年科学基金项目(No.82301364,No.82201580)Supported by the STI2030-Major Project of Ministry of Science and Technology(No.2021ZD0201808)and Youth Foundation of the National Natural Science Foundation of China(No.82301364,No.82201580) （No.82301364,No.82201580）
