西安交通大学学报（医学版）2025，Vol.46Issue(5)：775-782,8.DOI:10.7652/jdyxb202505009
生活方式与认知功能下降的关系:西安农村人群4年前瞻性队列研究
Correlation between lifestyle and cognitive decline in rural people aged 40 years and older in Xi'an:a 4-year prospective cohort study
摘要
Abstract
Objective To investigate the effect of lifestyle on cognitive decline in rural people aged 40 years and older in Xi'an.Methods This was a prospective cohort study.People aged 40 years and older in two villages in Huyi District were selected as the study population.They completed the baseline survey from October 2014 to March 2015 as well as two follow-up visits in 2016 and 2018,respectively.A comprehensive score of lifestyle was calculated based on factors including smoking,drinking,exercise,and diet collected at the baseline.The Mini-Mental State Examination(MMSE)was used to evaluate global cognitive function at both baseline and follow-up;a≥4-point decrease in MMSE score from the baseline was defined as marked cognitive decline.Multivariable Logistic regression,propensity score correction,and propensity score matching were used to investigate the relationship between lifestyle and cognitive decline.Results A total of 1 348 participants were ultimately enrolled and 56(4.2％)of them met the criteria for marked cognitive decline(△MMSE≥4-points).Among them,386(28.6％)people had smoking history,184(13.6％)were drinkers,214(15.9％)lacked physical activity,and 400(29.7％)ate a diet high in oil and salt.Generally,304(22.6％)met the definition of the unhealthy lifestyle(comprehensive score＜6),which means more than one of the four subscales was unhealthy or more than two were relatively unhealthy.Multivariable Logistic regression analysis showed that unhealthy lifestyle was positively associated with marked cognitive decline(OR=2.838,95％CI:1.302-5.525,P=0.005).Propensity-score adjusted model yielded very similar results(OR=2.786,95％CI:1.371-5.661,P=0.005).Propensity score matching was performed to further balance the differences in covariates between the two groups.Multivariate Logistic regression analysis conducted in the matched population revealed that the risk of marked cognitive decline was still higher in those with unhealthy lifestyle(OR=3.994,95％CI:1.582-12.176,P=0.006).Conclusion Unhealthy lifestyle is associated with an increased risk of cognitive decline in cognitively normal people aged 40 years and older.关键词
认知功能下降/危险因素/生活方式/队列研究/倾向性评分匹配Key words
cognitive decline/risk factor/lifestyle/cohort study/propensity score matching分类
医药卫生引用本文复制引用
周蓉,张彧,曹红梅,商苏杭,党亮君,魏珊,王敬谊,屈秋民,屈彦..生活方式与认知功能下降的关系:西安农村人群4年前瞻性队列研究[J].西安交通大学学报（医学版）,2025,46(5):775-782,8.基金项目
科技创新-2030(No.2021ZD0201808) （No.2021ZD0201808）
国家自然科学基金资助(No.82301364,No.82201580) （No.82301364,No.82201580）
陕西省自然科学基础研究计划项目(No.2021JM-277)Supported by STI2030-Major Project(No.2021ZD0201808),the National Natural Science Foundation of China(No.82301364,No.82201580),and the Natural Science Basic Research Program of Shaanxi Province(No.2021JM-277) （No.2021JM-277）
