西安交通大学学报（医学版）2025，Vol.46Issue(5)：783-788,6.DOI:10.7652/jdyxb202505010
颈动脉粥样硬化与认知障碍的关系:一项以西安市农村地区40岁及以上脑卒中高危人群为基础的横断面研究
Relationship between carotid atherosclerosis and cognitive impairment:a cross-sectional study based on a population aged 40 years and older at high risk of stroke in a rural area of Xi'an City
摘要
Abstract
Objective To explore the relationship between carotid atherosclerosis(CAS)and cognitive impairment in the stroke high-risk population aged 40 years and above in the rural area of Xi'an City and determine whether CAS is a risk factor for cognitive impairment.Methods In this study,stroke high-risk population found in the Community and Rural Population Stroke High-risk Group Screening and Intervention Project carried out in Huyi District,Xi'an City,from October 2014 to March 2015 were selected as the research subjects.Color Doppler ultrasound was used to evaluate CAS,and CAS was defined as:carotid intima-media thickness(CIMT)≥1.0 mm,or carotid arteries(including common carotid artery,carotid sinus,internal carotid artery,and external carotid artery)have atherosclerotic plaques,or carotid stenosis.Mini-Mental State Examination(MMSE)was used to assess cognitive function.The MMSE score lower than the cut-off value(illiteracy ≤17,primary school ≤ 20 points,and junior high school and above education level ≤24 points)is defined as cognitive impairment.The study population was grouped according to the presence of CAS or cognitive impairment;univariate difference test and bivariate logistic regression were used to analyze the relationship between CAS and cognitive impairment.Results A total of 451 subjects were included in the analysis.The average age of the subjects was(58.7±9.83)years old,and 44.3％were female.Among them,329 cases(72.9％)had CAS and 57 cases(12.6％)met the diagnostic criteria for cognitive impairment.The prevalence of cognitive impairment in CAS group was significantly higher than that in non-CAS group(14.6％vs.7.4％,P=0.041).Multivariate logistic regression analysis showed that cognitive impairment was significantly correlated with age(OR=1.121,95％CI:1.056-1.189,P＜0.001),but not with CAS(OR=1.008,95％CI:0.202-5.170,P=0.992).Conclusion No significant association between CAS and cognitive impairment was found in high stroke risk group aged 40 and above in rural areas of Xi'an.关键词
认知障碍/危险因素/颈动脉粥样硬化(CAS)/脑卒中/横断面研究Key words
cognitive impairment/risk factor/carotid atherosclerosis(CAS)/stroke/cross-sectional study分类
医药卫生引用本文复制引用
陈晨,高玲,商苏杭,党亮君,魏珊,王敬谊,王瑾,屈秋民,陆文惠..颈动脉粥样硬化与认知障碍的关系:一项以西安市农村地区40岁及以上脑卒中高危人群为基础的横断面研究[J].西安交通大学学报（医学版）,2025,46(5):783-788,6.基金项目
科技创新2030资助项目(No.2021ZD0201808) （No.2021ZD0201808）
国家自然科学基金资助项目(No.82301364,No.82201580) （No.82301364,No.82201580）
陕西省重点研究发展计划项目(No.2022SF-177,No.2023-YBSF-408)Supported by STI2030-Major Project(No.2021ZD0201808),the National Natural Science Foundation of China(No.82301364,No.82201580),and the Natural Science Basic Research Program of Shaanxi Province(No.2022SF-177,No.2023-YBSF-408) （No.2022SF-177,No.2023-YBSF-408）
