西安交通大学学报（医学版）2025，Vol.46Issue(5)：804-810,7.DOI:10.7652/jdyxb202505013
血浆β淀粉样蛋白与认知功能障碍的关系:西安市农村人群横断面研究
Relationship between plasma amyloid β and cognitive impairment:a cross-sectional study based on a population in a rural area of Xi'an,China
摘要
Abstract
Objective To explore the relationship between plasma amyloid-β(Aβ)and cognitive impairment.Methods A total of all villagers(aged 40 years and above)from two villages of Xi'an,China,were enrolled.A validated Chinese version of the Mini-Mental State Examination and neuropsychological battery were used to assess cognition.Levels of fasting plasma Aβ1-42 and Aβ1-40 were tested using commercial enzyme-linked immunosorbent assay(ELISA).Relationship between plasma Aβ and cognitive impairment was analyzed using Logistic regression analysis.Results Of the 1 314 enrolled subjects,1 180(89.80％)had normal cognition,85(6.47％)had suspected cognitive impairment,and 49(3.73％)had probable cognitive impairment.Univariate analysis showed that plasma Aβ1-42/Aβ1-40 ratio was higher in the suspected cognitive impairment group than in the probable cognitive impairment group(P＜0.05)and normal cognitive group(P＜0.05);plasma Aβ1-42 level in the suspected cognitive impairment group was higher than that in normal cognitive group(P＜0.05).The level of Aβ1-40 did not differ between the three groups.After correcting for confounding factors(including age,gender,degree of education,cognitive impairment risk factors,habits of living)in the multivariate Logistic regression analysis,the results were consistent with those in the univariate analysis.Conclusion Levels of plasma Aβ1-42 and Aβ1-42/Aβ1-40 ratio were elevated in patients with suspected cognitive impairment,indicating that elevated plasma Aβ1-42 and Aβ1-42/Aβ1-40 ratio may be more pronounced in early stage of cognitive impairment.They may be early biomarkers for cognitive impairment,which can help identify and intervene the disease earlier.关键词
阿尔茨海默病/生物标志物/血浆β淀粉样蛋白(Aβ)/社区人群/横断面研究Key words
Alzheimer's disease/biomarker/plasma amyloid-β(Aβ)/community population/cross-sectional study分类
医药卫生引用本文复制引用
胡童鑫,马欢,商苏杭,高玲,党亮君,王敬谊,屈秋民,王瑾..血浆β淀粉样蛋白与认知功能障碍的关系:西安市农村人群横断面研究[J].西安交通大学学报（医学版）,2025,46(5):804-810,7.基金项目
国家科技部科技创新2030-"脑科学与类脑研究"重大项目(No.2021ZD0201808)资助Supported by Science and Technology Innovation-2030(No.2021ZD0201808) （No.2021ZD0201808）
