心脑血管病防治2025，Vol.25Issue(7)：15-19,25,6.DOI:10.3969/j.issn.1009-816x.2025.07.004
原发性高血压患者血清高迁移率族蛋白B1水平与早期肾功能损伤相关性研究
Correlation between serum high mobility group box 1 protein level and early renal injury in patients with essential hypertension
摘要
Abstract
Objective To analyze the correlation between serum high mobility group box 1 protein(HMGB1)level and early renal injury in patients with essential hypertension,and to explore its predictive value for early renal injury.Methods A total of 268 patients with essential hypertension admitted to Hengshui People's Hospital from June 2021 to September 2022 were enrolled.Based on urinary microalbumin-to-creatinine ratio(UACR)measurements,the patients were divided into an early renal injury group(UACR 30-300 mg/g)and a non-early renal injury group(UACR<30 mg/g).Differences in systolic blood pressure(SBP),diastolic blood pressure(DBP),HMGB1,systemic immune-inflammation index(SII),and renal function indexes were compared between the two groups.Correlation analysis were performed between HMGB1 and other parameters in the early renal injury group.Logistic regression was used to analyze the influencing factors for early renal injury in essential hypertension.Patients in the non-early renal injury group underwent 1.5-year follow-up and were divided into the new early renal injury subgroup and non-new early renal injury subgroup according to UACR.Baseline serum HMGB1 levels at admission were compared between the two groups.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of HMGB1 for new early renal injury.Results The early renal injury group demonstrated higher levels of SBP,HMGB1,SII,cystatin C(CysC),β2-microglobulin(β2-MG),α1-microglobulin(α1-MG),and UACR compared to the non-early renal injury group(t/Z=2.090,13.722,-5.536,10.688,3.659,-8.361,18.001;all P<0.05),along with lower estimated glomerular filtration rate(eGFR)(t=4.525,P<0.05).The duration of hypertension in the early renal injury group was longer than that in the non-early renal injury group(Z=-1.972,P<0.05).Serum HMGB1 in the early renal injury group was positively correlated with SBP,SII,CysC,β2-MG,α1-MG,and UACR(r=0.249,0.325,0.531,0.283,0.477,0.577;P<0.05),while negatively correlated with eGFR(r=-0.239,P<0.05).Logistic regression analysis showed that levels of SBP,α1-MG,CysC,and HMGB1 were risk factors for early renal injury(OR=1.026,1.188,16.528,1.643;P<0.05).Baseline serum HMGB1 and CysC levels in the new early renal injury subgroup were higher than those in the non-new early renal injury subgroup(t=10.060,3.029;P<0.05).ROC curve analysis revealed an AUC of 0.888 for HMGB1 in predicting new early renal injury.Conclusion Serum HMGB1 level is associated with early renal injury in essential hypertension and demonstrates predictive value for new-onset cases in non-early renal injury patients.Dynamic monitoring of HMGB1 shows clinical utility for identifying high-risk population.关键词
原发性高血压/高迁移率族蛋白B1/早期肾功能损伤/全身免疫炎症指数Key words
Essential hypertension/High-mobility group box 1 protein/Early renal injury/Systemic immune-inflammation index引用本文复制引用
李勇,苏亚坤,张宏博,李原,李占虎,闫小菊..原发性高血压患者血清高迁移率族蛋白B1水平与早期肾功能损伤相关性研究[J].心脑血管病防治,2025,25(7):15-19,25,6.基金项目
河北省医学科学研究课题(20220456) （20220456）
衡水市科技局科技计划项目(2020014081Z) （2020014081Z）
