心脑血管病防治2025，Vol.25Issue(7)：30-34,5.DOI:10.3969/j.issn.1009-816x.2025.07.007
特异性促炎症消退介质治疗过度炎症反应的研究
Research on specialized proresolving mediators in the treatment of excessive inflammatory response
摘要
Abstract
Excessive and uncontrolled inflammation may be caused by signal transduction defect of proresolving mediators.As research progresses,it has been found that the resolution of inflammation is also an active process,mediated by specific lipid mediators,including lipoproteins,resolvins,protectins,and Maresins,which coordinate the restoration of underlying tissue homeostasis.As a result,lipid mediators have received increasing attention.The resolution of inflammation is a biosynthetically active process initiated and coordinated by a range of endogenous specialized proresolving mediators(SPMs).This article aims to delineate the biosynthetic pathways of SPMs and their key associated receptors,then discuss recent findings on their roles in promoting the resolution of inflammatory responses.A particular focus is placed on the functions of SPMs derived from polyunsaturated fatty acids and their potential therapeutic applications.关键词
特异性促炎症消退介质/过度炎症反应/炎症消退Key words
Specialized proresolving mediators/Excessive inflammatory response/Inflammation subsides引用本文复制引用
卢文娟,梅益斌,曾春来..特异性促炎症消退介质治疗过度炎症反应的研究[J].心脑血管病防治,2025,25(7):30-34,5.基金项目
浙江省自然科学基金资助项目(LTGY24H020004) （LTGY24H020004）
