现代妇产科进展2025，Vol.34Issue(10)：751-753,761,4.DOI:10.13283/j.cnki.xdfckjz.2025.10.004
肺癌宫颈转移的临床特征与诊疗分析
Clinical features,diagnosis and treatment of cervical metastasis from lung cancer
摘要
Abstract
Objective:To analyze the clinical characteristics and diagnosis/treatment of cervical metastasis from lung cancer through a systematic literature review.Methods:A system-atic literature search was conducted in PubMed,Wanfang,and CNKI databases to identify case reports on cervical metastasis of lung cancer.Clinical features,diagnostic approaches,and treat-ment outcomes were summarized.Results:Fourteen cases from 14 studies were included.The median patient age was 62 years(range:41～76).All cases(14/14,100%)involved lung ade-nocarcinoma,predominantly at stagesⅢand Ⅳ(91.7%).The primary symptoms were vaginal bleeding or abnormal discharge(71.4%).Diagnosis relied on pathology and immunohistochem-istry(TTF-1 positivity:100%;CK7 positivity:92.9%)and molecular testing.Systemic chemo-therapy(28.6%)and targeted therapy(35.7%)were the main treatments,while surgery and radiotherapy were limited to palliative intent.Targeted agents(gefitinib,osimertinib)signifi-cantly alleviated symptoms,but the median progression-free survival was only 8 months.Con-clusion:Cervical metastasis should be highly suspected in female lung cancer patients presen-ting with gynecological symptoms.Pathological and molecular testing optimizes diagnosis,and personalized targeted therapy may improve prognosis.关键词
肺癌/宫颈/转移/晚期Key words
Lung cancer/Cervix/Metastasis/Advanced stage分类
医药卫生引用本文复制引用
吴嘉雯,廖梓韵,陈钰,钟碧婷,张艺,欧阳振波..肺癌宫颈转移的临床特征与诊疗分析[J].现代妇产科进展,2025,34(10):751-753,761,4.基金项目
广东省颐养基金项目(No:JZ2022001-4) （No:JZ2022001-4）
广东省医学科学技术研究基金项目(No:B2023039) （No:B2023039）
