现代妇产科进展2025，Vol.34Issue(10)：762-767,773,7.DOI:10.13283/j.cnki.xdfckjz.2025.10.006
宫颈神经内分泌癌术后预后因素及辅助治疗的探索
Exploration of prognostic factors and adjuvant therapy in postoperative neuroendocrine cervical cancer
摘要
Abstract
Objective:To investigate the prognostic factors and the efficacy of postoper-ative treatment in patients with neuroendocrine carcinoma of the cervix(NECC),and to provide a reference for clinical treatment.Methods:Clinical and pathological data from 88 NECC pa-tients who underwent surgery between March 2014 and March 2024 were collected.Kaplan-Meier analysis was used to assess overall survival(OS)and progression-free survival(PFS),and the Cox proportional hazards model was employed to identify independent prognostic factors.The efficacy of different treatment modalities was compared.Results:Among the 88 NECC patients,the median OS was 23.0 months,and the median PFS was 15.0 months.Univariate analysis re-vealed that tumor stage,vascular cancer embolus,lymph node metastasis,and tumor size signifi-cantly affected OS and PFS(P<0.05).Multivariate analysis indicated that vascular cancer em-bolus was an independent adverse prognostic factor for both OS and PFS(P<0.05),while post-operative adjuvant chemotherapy was an independent protective factor(P<0.05).Patients re-ceiving the EP regimen had longer median OS and PFS compared to those receiving the TP or VAC regimens(P>0.05).Patients who received four or more cycles of postoperative chemother-apy had significantly better 5-year OS and PFS compared to those who received fewer than four cycles(P<0.05).Conclusion:Patients with NECC generally have a poor prognosis,especially those with vascular cancer embolus.Postoperative adjuvant chemotherapy can significantly im-prove prognosis,with the EP regimen potentially being the optimal choice.Immunotherapy targe-ting NECC may be beneficial,requiring further research to optimize treatment strategies.关键词
宫颈神经内分泌癌/预后/化疗/靶向治疗Key words
Neuroendocrine cervical cancer/Prognosis/Chemotherapy/Targeted therapy分类
医药卫生引用本文复制引用
沈法权,邵如玉,姚德生..宫颈神经内分泌癌术后预后因素及辅助治疗的探索[J].现代妇产科进展,2025,34(10):762-767,773,7.基金项目
广西自然科学基金项目(No:2022GXNSFAA035648) （No:2022GXNSFAA035648）
