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Characterization of preclinical radio ADME properties of ARV-471 for predicting human PK using PBPK modeling

Yifei He Chenggu Zhu Peng Lei Chen Yang Yifan Zhang Yuandong Zheng Xingxing Diao

药物分析学报（英文）2025，Vol.15Issue(5)：1145-1159,15.

药物分析学报（英文）2025，Vol.15Issue(5)：1145-1159,15.DOI:10.1016/j.jpha.2024.101175

Characterization of preclinical radio ADME properties of ARV-471 for predicting human PK using PBPK modeling

Yifei He ¹Chenggu Zhu ²Peng Lei ³Chen Yang ³Yifan Zhang ³Yuandong Zheng ³Xingxing Diao¹

作者信息

1. Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203,China||University of Chinese Academy of Sciences,Beijing,100049,China
2. Wuxi Beita Pharmatech Co.,Ltd.,Wuxi,Jiangsu,214437,China
3. Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203,China
折叠

摘要

关键词

PROTAC/Vepdegestrant(ARV-471)/Radiolabeling/In vitro-in vivo extrapolation(IVIVE)/Physiologically based pharmacokinetic(PBPK)model

Key words

PROTAC/Vepdegestrant(ARV-471)/Radiolabeling/In vitro-in vivo extrapolation(IVIVE)/Physiologically based pharmacokinetic(PBPK)model

引用本文复制引用

Yifei He,Chenggu Zhu,Peng Lei,Chen Yang,Yifan Zhang,Yuandong Zheng,Xingxing Diao..Characterization of preclinical radio ADME properties of ARV-471 for predicting human PK using PBPK modeling[J].药物分析学报（英文）,2025,15(5):1145-1159,15.

基金项目

The study was partially financially supported by the National Natural Science Foundation of China(Grant Nos.:82373938,82104275,and 82204585),Key Technologies R&D Program of Guangdong Province,China(Grant No.:2023B1111030004),and National Key R&D Program of China(Grant No.:2022YFF1202600). （Grant Nos.:82373938,82104275,and 82204585）

药物分析学报（英文）

ISSN：2095-1779

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