药物分析学报（英文）2025，Vol.15Issue(6)：1277-1290,14.DOI:10.1016/j.jpha.2025.101295
Perturbation response scanning of drug-target networks:Drug repurposing for multiple sclerosis
Perturbation response scanning of drug-target networks:Drug repurposing for multiple sclerosis
Yitan Lu 1Wenying Yan 2Zhongjie Liang 3Qifei Cong 4Guang Hu 5Ziyun Zhou 1Qi Li 6Bin Yang 1Xing Xu 1Yu Zhu 7Mengjun Xie 6Yuwan Qi 6Fei Xiao1
作者信息
- 1. MOE Key Laboratory of Geriatric Diseases and Immunology,Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective Medicine,Department of Bioinformatics and Computational Biology,School of Life Sciences,Suzhou Medical College of Soochow University,Suzhou,215123,China
- 2. Department of Bioinformatics,Center for Systems Biology,School of Basic Medical Sciences,Suzhou Medical College of Soochow University,Suzhou,215123,China||Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development,Soochow University,Suzhou,215123,China
- 3. MOE Key Laboratory of Geriatric Diseases and Immunology,Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective Medicine,Department of Bioinformatics and Computational Biology,School of Life Sciences,Suzhou Medical College of Soochow University,Suzhou,215123,China||Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development,Soochow University,Suzhou,215123,China
- 4. Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases,Soochow University,Suzhou,215123,China||Department of Neurology and Clinical Research Center of Neurological Disease,The Second Affiliated Hospital of Soochow University,Suzhou,215004,China||Department of Nephrology,The Second Affiliated Hospital of Soochow University,Suzhou,215004,China
- 5. MOE Key Laboratory of Geriatric Diseases and Immunology,Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective Medicine,Department of Bioinformatics and Computational Biology,School of Life Sciences,Suzhou Medical College of Soochow University,Suzhou,215123,China||Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development,Soochow University,Suzhou,215123,China||Key Laboratory of Alkene-carbon Fibres-based Technology & Application for Detection of Major Infectious Diseases,Soochow University,Suzhou,215123,China||Jiangsu Key Laboratory of Infection and Immunity,Soochow University,Suzhou,215123,China
- 6. Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases,Soochow University,Suzhou,215123,China
- 7. Department of Pharmacology,University of Cambridge,Cambridge,UK
- 折叠
摘要
关键词
Network perturbations/Mechanism of action/Multiple sclerosis/HTR2BKey words
Network perturbations/Mechanism of action/Multiple sclerosis/HTR2B引用本文复制引用
Yitan Lu,Wenying Yan,Zhongjie Liang,Qifei Cong,Guang Hu,Ziyun Zhou,Qi Li,Bin Yang,Xing Xu,Yu Zhu,Mengjun Xie,Yuwan Qi,Fei Xiao..Perturbation response scanning of drug-target networks:Drug repurposing for multiple sclerosis[J].药物分析学报（英文）,2025,15(6):1277-1290,14.基金项目
This work was supported by the National Natural Science Foundation of China(Grant Nos.:32271292,31872723,32200778,and 22377089),the Jiangsu Students Innovation and Entrepre-neurship Training Program,China(Program No.:202210285081Z),the Project of MOE Key Laboratory of Geriatric Diseases and Immunology,China(Project No.:JYN202404),Proj-ect Funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions,Natural Science Foundation of Jiangsu Province,China(Project No.:BK20220494),Suzhou Medical and Health Technology Innovation Project,China(Grant No.:SKY2022107),the Clinical Research Center of Neuro-logical Disease in The Second Affiliated Hospital of Soochow University,China(Grant No.:ND2022A04),State Key Laboratory of Drug Research(Grant No.:SKLDR-2023-KF-05),Jiangsu Shuang-chuang Program for Doctor,Young Science Talents Promotion Project of Jiangsu Science and Technology Association(Program No.:TJ-2023-019),Young Science Talents Promotion Project of Suzhou Science and Technology Association,Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,and startup funding(Grant Nos.:NH21500221,NH21500122,and NH21500123)to Qifei Cong. （Grant Nos.:32271292,31872723,32200778,and 22377089）
