现代中西医结合杂志2025，Vol.34Issue(14)：1899-1904,2024,7.DOI:10.3969/j.issn.1008-8849.2025.14.001
心衰Ⅰ号治疗急性心肌梗死后心力衰竭疗效观察
Efficacy of heart failure prescription No.1 on heart failure after acute myocardial infarction
摘要
Abstract
Objective It is to observe the clinical efficacy of heart failure prescription No.1 on heart failure with syn-drome of Qi-Yin deficiency and phlegm-blood stasis impediment and obstruction after acute myocardial infarction(AMI)and its effect on blood liquid and echocardiographic parameters.Methods A total of 60 patients with heart failure with syn-drome of Qi-Yin deficiency and phlegm-blood stasis impediment and obstruction after AMI treated in the Affiliated Hospital of Nanjing University of Chinese Medicine from June 2021 to February 2023 were randomly divided into treatment group and control group,with 30 patients in each group.The control group was treated with standard therapy including antiplatelet a-gents,lipid-lowering drugs,and drugs for treating heart failure,the treatment group was treated with heart failure prescrip-tion No.1 on the basis of the therapy in the control group.Both groups were treated for 8 weeks.The efficacies of tradition-al Chinese medicine syndrome of the two groups were evaluated after 8 weeks of therapy,the levels of lipid indicators[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]and echocardiographic parameters[left ventricular end-diastolic volume(LVEDV),left ventricular end-systol-ic volume(LVESV),left ventricular ejection fraction(LVEF),wall motion score index(WMSI)and global longitudinal strain(GLS)absolute value]of patients in the two groups were compared before treatment and after 8 weeks of treatment,the occurrence of adverse drug reactions in the two groups was recorded.Results After 8 weeks of treatment,the total effec-tive rate of traditional Chinese medicine syndrome in the treatment group was 96.7%(29/30),while that in the control group was 90.0%(27/30),the total effective rate in the treatment group was significantly higher than that in the control group(P<0.05).After 8 weeks of treatment,the serum levels of TC and LDL-C of patients in both groups were signifi-cantly lower than those before treatment(all P<0.05),and the levels of TC and LDL-C in the treatment group were sig-nificantly lower than those in the control group(both P<0.05),there was no significant differences in the serum levels of TG and HDL-C between the two groups before and after treatment(all P>0.05).After 8 weeks of treatment,the LV-EDV,LVESV and WMSI of patients in the treatment group were significantly lower(all P<0.05),while LVEF and GLS absolute values were significantly higher than those before treatment(all P<0.05),and the LVESV and WMSI were sig-nificantly lower(both P<0.05),while the LVEF and GLS absolute values were significantly higher than those in the con-trol group(all P<0.05).No serious adverse reactions occurred in either group during the treatment period.Conclusion Heart failure prescription No.1 combined with conventional therapy can effectively and safely improve the traditional Chi-nese medicine syndrome,regulate blood lipid,alleviate ventricular remodeling and enhance cardiac function of patients with heart failure with syndrome of Qi-Yin deficiency and phlegm-blood stasis impediment and obstruction after AMI.关键词
急性心肌梗死/心力衰竭/心衰Ⅰ号/室壁运动记分指数/整体纵向应变/心室重构Key words
acute myocardial infarction/heart failure/heart failure prescription No.1/wall motion score index/glob-al longitudinal strain/ventricular remodeling分类
医药卫生引用本文复制引用
王令谆,何安霞,徐天,李婕,韩捷,湛武逸,陈建东..心衰Ⅰ号治疗急性心肌梗死后心力衰竭疗效观察[J].现代中西医结合杂志,2025,34(14):1899-1904,2024,7.基金项目
国家自然科学基金资助项目(81973763) （81973763）
江苏省中医药科技发展计划项目(YB2020007) （YB2020007）
南京市中医药传承发展示范试点资助项目(NJCC-ZJ-202422) （NJCC-ZJ-202422）
