现代中西医结合杂志2025，Vol.34Issue(14)：1905-1910,1931,7.DOI:10.3969/j.issn.1008-8849.2025.14.002
出血性中风1号方和2号方治疗出血性中风急性期风火上扰证临床疗效及安全性再评价
Re-evaluation of clinical efficacy and safety of self-prescribed hemorrhagic stroke prescription No.1 and No.2 in the treatment of acute hemorrhagic stroke with syndrome of wind-fire harassing the upper
摘要
Abstract
Objective It is to explore the clinical efficacy and safety of self-prescribed hemorrhagic stroke prescription No.1 and No.2 in the treatment of patients with acute hemorrhagic stroke with syndrome of wind-fire harassing the upper.Methods A total of 312 patients with acute hemorrhagic stroke with syndrome of wind-fire harassing the upper treated in Ankang Hospital of Traditional Chinese Medicine and Affiliated Hospital of Shaanxi University of Chinese Medicine from December 2021 to December 2023 were selected and divided into a control group(n=152)and an observation group(n=160)according to the treatment wishes of the patients and their families.The control group was treated according to rele-vant western medical guidelines,the observation group was treated with hemorrhagic stroke prescription No.1(within 7 days of onset)and hemorrhagic stroke prescription No.2(8-21 days after onset)orally according to the onset of the dis-ease based on the treatment of the control group.The hematoma volume,edema volume,stroke syndrome score,NIHSS score of neurological function,Barthel score of activities of daily living,Fugl-Meyer score of motor function and serum lev-els of homocysteine(Hcy),neuron-specific enolase(NSE)and tumor necrosis factor-α(TNF-α)of patients in the two groups were observed and compared at admission and on the 7th and 21st day of treatment,the clinical efficacy after 21 days of treatment and adverse reactions during the treatment period were evaluated.Results On the 21st day of treatment,the hematoma volume,edema volume,stroke syndrome scores,NIHSS scores and serum levels of Hcy,NSE and TNF-α of patients in the two groups were significantly lower(all P<0.05),while the Barthel scores and Fugl-Meyer scores were sig-nificantly higher than those at admission(all P<0.05);Furthermore,the hematoma volume,edema volume,stroke syn-drome scores,NIHSS scores and serum levels of Hcy,NSE and TNF-α of patients in the observation group were significant-ly lower(all P<0.05),while the Barthel scores and Fugl-Meyer scores were significantly higher than those of patients in the control group(all P<0.05).The total effective rate of treatment was 94.38％(151/160)in the observation group and 85.53％(130/152)in the control group,the rate of the observation group was significantly higher than that of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Western medicine treatment regimen combined with hemorrhagic stroke prescription No.1 and No.2 are significantly effective in the treatment of patients with acute hemorrhagic stroke with syndrome of wind-fire harassing the upper.This treatment regimen can promote the absorption of hematoma and surrounding edema,alleviate inflammatory reactions and restore neurological function with good safety.关键词
出血性中风1号方/出血性中风2号方/出血性中风风火上扰证/生活能力/同型半胱氨酸/神经元特异性烯醇化酶/肿瘤坏死因子-αKey words
hemorrhagic stroke prescription No.1/hemorrhagic stroke prescription No.2/hemorrhagic stroke/syn-drome of wind-fire harassing the upper/Hcy/NSE/TNF-α分类
医药卫生引用本文复制引用
唐勇,王凯,范小璇,陈亮,王晓玲,陈向荣..出血性中风1号方和2号方治疗出血性中风急性期风火上扰证临床疗效及安全性再评价[J].现代中西医结合杂志,2025,34(14):1905-1910,1931,7.基金项目
陕西省科学技术协会青年人才托举计划项目(20230338) （20230338）
陕西省中医药管理局中医药传承创新暨"秦药"开发重点科学研究项目(2021-01-GJ-019) （2021-01-GJ-019）
安康市科学技术研究发展计划项目(AK2021-SF-12) （AK2021-SF-12）
安康市青年科技新星项目(AK2023PD-KJXX-03) （AK2023PD-KJXX-03）
