现代中西医结合杂志2025，Vol.34Issue(14)：1926-1931,6.DOI:10.3969/j.issn.1008-8849.2025.14.005
气郁痰阻型、痰结血瘀型桥本甲状腺炎与临床指标的相关性研究
Correlation between clinical indicators and Hashimoto thyroiditis with syndrome of Qi stagnation and phlegm obstruction or with syndrome of phlegm binding and blood stasis
摘要
Abstract
Objective It is to explore the correlation between syndrome types ofHashimoto thyroiditis(HT)of with syn-drome of Qi stagnation and phlegm obstruction or with syndrome of phlegm binding and blood stasis and age,body mass in-dex(BMI),biochemical indexes and ultrasound image.Methods A total of 122 patients with HT who visited the outpa-tient clinic of the Department of Metabolic Diseases of Shanxi Provincial Hospital of Traditional Chinese Medicine from July 2023 to June 2024 were enrolled,and their data of the four diagnostic methods were collected via questionnaire surveys,and syndrome differentiation classification was completed,62 cases were finally classified as syndrome of Qi stagnation and phlegm obstruction,and 60 cases as syndrome of phlegm binding and blood stasis.The age,BMI,thyroid function indica-tors[serum levels of free triiodothyronine(FT3),free thyroxine(FT4),thyroid-stimulating hormone(TSH)],autoanti-bodies[serum levels of thyroid peroxidase antibodies(TPOAb),thyroglobulin antibodies(TGAb)],serum content of se-lenium,and thyroid ultrasound parameters(thyroid isthmus thickness,blood flow signal classification)were compared a-mong patients with different syndromes to explore the correlation between clinical indicators and traditional Chinese medi-cine syndromes.Results There were no significant differences in age,levels of thyroid function indicators and autoantibod-ies,thyroid isthmus thickness and blood flow signal classification between the two traditional Chinese medicine syndrome types(all P>0.05);compared with the patients with syndrome of phlegm binding and blood stasis,the patients with qi stagnation and phlegm obstruction had a lower serum content of selenium content and a higher BMI(both P<0.05).Uni-variate binary Logistic regression analysis revealed that age(OR=1.046,P<0.05),FT3 level(OR=0.673,P<0.05),and BMI(OR=0.731,P<0.05)were factors influencing the pattern differentiation of syndrome of phlegm bind-ing and blood stasis and syndrome of Qi stagnation and phlegm obstruction.The younger the age,the higher the FT3 and BMI,the lower the possibility of syndrome of Qi stagnation and phlegm obstruction,and the higher the possibility of syn-drome of phlegm binding and blood stasis were.Further analysis revealed a negative correlation between serum selenium content and the risk of syndrome of Qi stagnation and phlegm obstruction in patients aged 18-44 years.Conclusion Com-pared with syndrome of phlegm binding and blood stasis,the HT patients with syndrome of Qi stagnation and phlegm ob-struction had lower age and serum selenium content,and higher FT3 and BMI.The relationship between HT syndrome type and selenium content is related to age,which can provide some evidences for the clinical diagnosis and treatment of HT in both Chinese and western medicine.关键词
桥本甲状腺炎/证型/临床指标/硒含量/相关性Key words
Hashimoto thyroiditis/syndrome type/clinical indicators/selenium content/correlation分类
医药卫生引用本文复制引用
戴赫盈,吕蕾,张维亮,郭晓霞,焦云红,樊晓红,董琦,宋微,王小梅..气郁痰阻型、痰结血瘀型桥本甲状腺炎与临床指标的相关性研究[J].现代中西医结合杂志,2025,34(14):1926-1931,6.基金项目
山西省中医药管理局科研课题计划项目(2023ZYYB2002) （2023ZYYB2002）
