疑难病杂志2025，Vol.24Issue(9)：1063-1068,6.DOI:10.3969/j.issn.1671-6450.2025.09.008
血清Claudin-5、BTP在重症急性胰腺炎合并急性肾损伤患者中的表达及与疾病严重程度的相关性
Expression of serum Claudin-5 and BTP in patients with severe acute pancreatitis complicated by acute kidney injury and the correlation with disease severity
摘要
Abstract
Objective To investigate the expression of serum Claudin-5 and β-trace protein(BTP)in patients with severe acute pancreatitis(SAP)complicated with acute kidney injury(AKI)and its correlation with the severity of the dis-ease.Methods A total of 135 SAP patients admitted to the Department of Gastroenterology,Affiliated Xidian Group Hospital of Shaanxi University of Traditional Chinese Medicine from January 2019 to August 2024 were selected.According to whether AKI was combined,they were divided into AKI group and non-AKI group.According to the degree of illness,they were divided into stage 1 SAP combined with AKI group,stage 2 SAP combined with AKI group,and stage 3 SAP combined with AKI group.The levels of serum Claudin-5 and BTP were detected by enzyme-linked immunosorbent assay.The relation-ship between serum Claudin-5,BTP and SAP combined with AKI was analyzed by multivariate Logistic regression analysis.ROC curve was used to analyze the predictive efficiency of serum Claudin-5 and BTP.Results The incidence of AKI in 135 patients with SAP was 44.44％(60/135).Compared with the non-AKI group,the serum levels of Claudin-5 and BTP in the AKI group were increased(t/P=7.486/＜0.001,8.502/＜0.001);The levels of serum Claudin-5 and BTP in stage 1 SAP com-bined with AKI group,stage 2 SAP combined with AKI group and stage 3 SAP combined with AKI group increased in turn(F/P=36.526/＜0.001,21.304/＜0.001).High APACHE Ⅱ score,high serum creatinine,high Claudin-5 and high BTP were in-dependent risk factors for SAP complicated with AKI[OR(95％CI)=3.375(1.123-10.147),1.025(1.010-1.041),1.001(1.000-1.001),1.320(1.130-1.542)];The area under the curve of serum Claudin-5,BTP levels and the combination of the two in pre-dicting SAP with AKI were 0.772,0.784 and 0.873,respectively.The combination of the two was greater than the AUC predic-ted by serum Claudin-5 and BTP levels alone(Z/P=2.992/0.004,3.071/0.003).Conclusion The increase of serum Claudin-5 and BTP levels is related to the occurrence and severity of SAP combined with AKI.The combination of serum Claudin-5 and BTP levels has a high predictive efficiency for SAP combined with AKI.关键词
重症急性胰腺炎/急性肾损伤/Claudin-5/β痕迹蛋白/疾病严重程度Key words
Severe acute pancreatitis/Acute kidney injury/Claudin-5/β-trace protein/Disease severity分类
医药卫生引用本文复制引用
张萌,张鹏飞,许怀利,杨琦,陈梦楠..血清Claudin-5、BTP在重症急性胰腺炎合并急性肾损伤患者中的表达及与疾病严重程度的相关性[J].疑难病杂志,2025,24(9):1063-1068,6.基金项目
陕西省重点研发计划社会发展领域项目(2021SF-347) Shaanxi Province Key R & D Plan Social Development Field Project(2021SF-347) （2021SF-347）
