疑难病杂志2025，Vol.24Issue(9)：1073-1077,5.DOI:10.3969/j.issn.1671-6450.2025.09.010
西格列汀联合胰岛素、贝那普利对糖尿病肾病患者肾功能、血管内皮功能及血清NLR、galectin-3、SFRP5的影响
Effects of sitagliptin on renal function,endothelial function and serum NLR,galectin-3 and SFRP5 in patients with diabetic nephropathy
摘要
Abstract
Objective To determine the effects of sitagliptin on renal function,endothelial function,serum neutrophil-to-lymphocyte ratio(NLR),galectin-3,and secreted frizzled-related protein 5(SFRP5)in patients with diabetic ne-phropathy.Methods A total of 108 patients with diabetic nephropathy treated in our hospital from October 2021 to May 2024 were selected and divided into two groups based on the random number table method,with 54 patients in each group.The control group received conventional insulin combined with benazepril treatment,and the observation group received addi-tional sitagliptin treatment on the basis of the control group's regimen.The differences in renal function indices,endothelial function-related indices,NLR,galectin-3,and SFRP5 levels were compared between the two groups.Results After 12 weeks of treatment,the levels of SCr,BUN,and β2-MG in the observation group were lower than those in the control group(t/P=9.482/＜0.001,4.287/＜0.001,9.242/＜0.001);the levels of NO and ET in the observation group were higher/lower than those in the control group(t/P=23.298/＜0.001,35.936/＜0.001);the neutrophil count,lymphocyte count,and NLR in the observation group were lower than those in the control group(t/P=16.818/＜0.001,6.256/＜0.001,8.132/＜0.001);the serum levels of galectin-3 and SFRP5 in the observation group were lower/higher than those in the control group(t/P=3.435/0.001,5.099/＜0.001).Con-clusion Sitagliptin can improve renal function and vascular endothelial function in patients with diabetic nephropathy,and can also regulate the levels of serum NLR,galectin-3,and SFRP5.关键词
糖尿病肾病/西格列汀/肾功能/血管内皮功能/中性粒细胞与淋巴细胞比值/半乳糖凝集素-3/分泌型卷曲蛋白5Key words
Diabetic nephropathy/Sitagliptin/Renal function/Vascular endothelial function/Neutrophil-to-lymphocyte ratio/Galectin-3/Secreted frizzled-related protein 5分类
医药卫生引用本文复制引用
李利萍,胡杨,颜建军,张楠,程木子,张丽莎,张文静,程玲..西格列汀联合胰岛素、贝那普利对糖尿病肾病患者肾功能、血管内皮功能及血清NLR、galectin-3、SFRP5的影响[J].疑难病杂志,2025,24(9):1073-1077,5.基金项目
河北省医学科学研究课题计划(20220486) Hebei Provincial Medical Science Research Project(20220486) （20220486）
