中国骨伤2025，Vol.38Issue(8)：816-821,6.DOI:10.12200/j.issn.1003-0034.20230935
人表皮生长因子凝胶治疗重度脊柱畸形患者头盆环术后针道感染
Human epidermal growth factor gel for pin tract infection following halo-pelvic ring traction procedure in patients with severe spinal deformity
摘要
Abstract
Objective To explore the efficacy and safety of human epidermal growth factor gel in the treatment of pin tract infections after surgery in patients with severe spinal deformity.Methods A retrospective case-control study was conducted to analyze the clinical data of 26 patients with pin tract infections after skull-pelvic ring traction for severe spinal deformity admit-ted from February 2019 to May 2022.Among them,11 were male and 15 were female;the age ranged from 18 to 31 years,with an average of(24.1±4.3)years;the Cobb angle ranged 80.3° to 120.7°,with an average of(88.6±10.2)°;there were 52 iliac traction pins,104 pin tract openings,and 38 pin tract infections.According to the Checketts-Otterbum classification,there were 11 infections of grade Ⅰ,13 infections of grade Ⅱ,10 infections of grade Ⅲ,and 4 infections of grade Ⅳ.The patients were divided into the conventional dressing change group(13 cases)and the growth factor group(13 cases)by coin flipping.Clinical efficacy was evaluated by recording the visual analogue scale(VAS)score during dressing change,duration of dressing change,cost of dressing change,positive rate of bacterial culture,wound improvement rate,and wound improvement time.Re-sults There were no statistically significant differences in VAS or duration of dressing change between the two groups(P＞0.05).The cost of dressing change was(800.0±59.5)yuan in the conventional dressing change group and(1 179.5±80.9)yuan in the growth factor group,with a statistically significant difference(P＜0.05).There was no statistically significant differ-ence in the positive rate of bacterial culture between the two groups(P＞0.05).In the conventional dressing change group,within 20 pin tract infections,2 infections achieved wound healing,7 infections showed improvement,and 11 infections were ineffective;in the growth factor group,within 18 pin tract infections 5 infections achieved wound healing,8 infections showed improvement,and 5 infections were ineffective,with a statistically significant difference between the two groups(P＜0.05).The wound healing time was(22.8±4.9)days in the conventional dressing change group and(14.2±2.5)days in the growth factor group,with a statistically significant difference(P＜0.05).No complications occurred in either group.Conclusion The applica-tion of human epidermal growth factor gel in the treatment of pin tract infections after skull-pelvic ring surgery in patients with severe spinal deformity is easy to operate,does not increase patient pain,and has significant efficacy.It shortens wound healing time,effectively promotes wound healing,and has good safety and high cost-effectiveness.关键词
表皮生长因子/针道感染/头盆环牵引/脊柱侧弯畸形/外科治疗Key words
Epidermal growth factor/Pin tract infection/Halo-pelvic ring traction/Scoliosis deformity/Surgical treatment分类
医药卫生引用本文复制引用
楼宇梁,洪锋,王灿锋,费慧,杜伟斌,全仁夫..人表皮生长因子凝胶治疗重度脊柱畸形患者头盆环术后针道感染[J].中国骨伤,2025,38(8):816-821,6.基金项目
杭州市医药卫生科技计划项目(编号:B20220021)Hangzhou Medical and Health Science and Technology Program(No.B20220021) （编号:B20220021）
