中国美容医学2025，Vol.34Issue(10)：27-30,4.
氧化石墨烯修饰的聚醚酮酮复合材料的成骨性能研究
Study on Osteogenic Properties of Polyetherketoneketone Modified by Graphene Oxide
王煜慧 1王海锋 1刘亚男1
作者信息
- 1. 首都医科大学康复医学院,中国康复研究中心,北京博爱医院口腔科 北京 100068
- 折叠
摘要
Abstract
Objective To study the effect of graphene oxide(GO)modified polyetherketoneketone(PEKK)on the proliferation and osteogenic differentiation of osteoblasts.Methods PEKK was vulcanized and treated with graphene oxide to prepare GO-SPEKK composites.MC3-T3 cells were co-cultured with PEKK,SPEKK and GO-SPEKK respectively.The experiment was divided into PEKK group,SPEKK group and GO-SPEKK group.The biological activity of MC3-T3 cells was detected by CCK-8,and the effects of different scaffolds on the survival status of MC3-T3 cells were judged.QRT-PCR was used to detect the expression levels of osteogenesis-related genes RUNX2,COL-1 and OCN.Results The results of CCK-8 showed that GO-SPEKK composite could promote the proliferation of MC3-T3 cells(P＜0.001),while SPEKK reduced the biological activity of MC3-T3 cells(P＜0.05).The results of qRT-PCR showed that the expression of OCN in GO-SPEKK group increased at 7 days(P＜0.05),and the expression of RUNX2 and COL-1 was significantly different(P＜0.01).Conclusion GO-SPEKK composite can improve the performance of PEKK scaffold to some extent and promote the osteogenesis of MC3-T3 cells.关键词
聚醚酮酮/氧化石墨烯/MC3-T3细胞/成骨性能Key words
polyetherketoneketone/graphene oxide/MC3-T3 cells/osteogenic property分类
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王煜慧,王海锋,刘亚男..氧化石墨烯修饰的聚醚酮酮复合材料的成骨性能研究[J].中国美容医学,2025,34(10):27-30,4.
