中国实验动物学报2025，Vol.33Issue(8)：1178-1197,20.DOI:10.3969/j.issn.1005-4847.2025.08.008
放射性心脏病动物模型研究进展
Progress in animal models of radiation-induced heart disease
摘要
Abstract
Radiation-induced heart disease(RIHD)is a severe complication in patients with thoracic cancer undergoing radiotherapy,with important impacts on long-term survival among cancer survivors.There is an urgent need to investigate the pathogenesis of RIHD and to develop effective therapeutic agents,and the establishment of high-quality RIHD animal models is pivotal to addressing these issues.This review summarizes the critical factors to consider in establishing RIHD animal models,including species selection,radiation type,dosage,fractionation,and target fields,and modeling timeline,along with the evaluation method and success criteria.We also consider the potential pathogenic mechanisms underlying RIHD,including DNA damage,oxidative stress,inflammatory responses,mitochondrial dysfunction,renin-angiotensin-aldosterone system activation,and myocardial fibrosis,as well as their interrelationships.These insights provide a comprehensive reference framework for constructing RIHD animal models and advancing mechanistic investigations into this condition.关键词
放射性心脏病/动物模型/评价标准/机制研究Key words
radiation-induced heart disease/animal models/evaluation criteria/mechanism research分类
生物科学引用本文复制引用
刘佳坤,蒋虎刚,刘爱,王夏颖,马静,石杨洋,赵信科,李应东..放射性心脏病动物模型研究进展[J].中国实验动物学报,2025,33(8):1178-1197,20.基金项目
国家自然科学基金(82360926).Funded by National Natural Science Foundation of China(82360926). （82360926）
