中国实验动物学报2025，Vol.33Issue(8)：1198-1210,13.DOI:10.3969/j.issn.1005-4847.2025.08.009
斑马鱼模型在骨骼遗传病中的研究进展
Research progress in zebrafish models of skeletal genetic diseases
摘要
Abstract
Skeletal genetic diseases are characterized by disorders in bone development and growth throughout the body.Such diseases often present clinically with pathological manifestations such as head and limb deformities and scoliosis,which can seriously affect patient quality of life.The Nosology of genetic skeletal disorders:2023 revision,recognizes 41 major categories,involving 552 genes;however,the pathogenic mechanisms of around half of all bone genetic diseases remain unclear.As a new type of model animal,zebrafish have a highly conserved skeletal development process and regulatory mechanism compared with mammals.They also have the advantages of small size,strong reproductive ability,short reproductive cycle,and transparent embryos,potentially making them suitable for studying the pathogenesis of human skeletal genetic diseases.This review focuses on progress in the application of zebrafish models in research related to human skeletal genetic diseases.We carried out an extensive literature review and selected nine major categories of skeletal genetic disorders for detailed discussion,including fibroblast growth factor receptor 3 chondrodysplasias,type 2 collagen disorders,and type 11 collagen disorders.This article summarizes the disease overview,zebrafish model construction,and their research significance,with the aim of providing a reference for in-depth research on the pathogenesis of human skeletal genetic diseases.关键词
斑马鱼/模式动物/骨骼遗传病Key words
zebrafish/model animal/skeletal genetic diseases分类
生物科学引用本文复制引用
李庚泽,孙先定..斑马鱼模型在骨骼遗传病中的研究进展[J].中国实验动物学报,2025,33(8):1198-1210,13.基金项目
中国博士后科学基金(2024T171107).Funded by China Postdoctoral Science Foundation(2024T171107). （2024T171107）
