化疗药物诱导的胃肠黏膜损伤动物模型研究进展OA北大核心
Research progress in animal models of chemotherapy-induced gastrointestinal mucosal injury
在全球癌症发病率逐年增加背景下,化疗药物诱导的胃肠黏膜损伤已成为影响患者治疗预后的重要因素,且缺乏有效治疗药物.因此,亟需建立更加理想的化疗药物诱导的胃肠黏膜损伤动物模型,以研究其发病机制,开发相关治疗药物.本文对2019-2024年期间发表的相关文献进行综述,从实验动物的选择、化疗药物及造模方式、模型评价指标及应用等方面进行总结分析,并提出当前模型存在的问题:缺乏统一标准的造模方法、缺少肿瘤背景的模型研究、新型细胞死亡机制的研究尚浅.此外整理文献后发现中医药治疗逐渐成为研究热点,在治疗胃肠黏膜损伤中展现出潜力,未来应继续挖掘有效药物,以丰富化疗后胃肠黏膜损伤的干预治疗手段.
The global incidence rate of cancer is increasing yearly,and chemotherapy-induced gastrointestinal mucosal injury has become a crucial factor affecting patients'therapeutic prognosis;however,there is currently a lack of effective therapeutic drugs to address this issue.There is thus an urgent need to establish more ideal animal models of chemotherapy-induced gastrointestinal mucosal injury,to support the exploration of its pathogenesis and the development of therapeutic drugs.This review considered relevant literature published during the period from 2019 to 2024,to provide a comprehensive summary and analysis from several perspectives,including the selection of experimental animals,chemotherapeutic drugs and modeling method,evaluation indicators,and practical applications.Furthermore,we highlight several existing issues with current models,including the lack of standardized modeling method,insufficient research on models with a tumor background,and inadequate exploration of novel cell death mechanisms.This collation of the literature also revealed the gradual emergence of traditional Chinese medicine as a research hotspot,with potential for the treatment of gastrointestinal mucosal injury.Further studies of effective medicines are warranted to identify interventional strategies for chemotherapy-induced gastrointestinal mucosal injury.
张以涵;黄珍祯;樊海艇;吴文斌;张超超;米金霞
上海中医药大学公共健康学院,上海 201203上海中医药大学实验动物中心,上海 201203上海中医药大学实验动物中心,上海 201203上海中医药大学实验动物中心,上海 201203上海中医药大学实验动物中心,上海 201203上海中医药大学公共健康学院,上海 201203
生物科学
化疗胃肠黏膜损伤动物模型造模方法发病机制
Chemotherapygastrointestinal mucosal injuryanimal modelmodeling methodpathogenesis
《中国实验动物学报》 2025 (8)
1235-1246,12
上海中医药大学科技发展基金项目(23KFL007),上海中医药大学公共健康学院学科建设项目(GJ202201).Funded by Science and Technology Development Fund Project of Shanghai University of Traditional Chinese Medicine(23KFL007),Academic Discipline Construction Project for School of Public Health in Shanghai University of Traditional Chinese Medicine(GJ202201).
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