中国实验动物学报2025，Vol.33Issue(8)：1235-1246,12.DOI:10.3969/j.issn.1005-4847.2025.08.012
化疗药物诱导的胃肠黏膜损伤动物模型研究进展
Research progress in animal models of chemotherapy-induced gastrointestinal mucosal injury
摘要
Abstract
The global incidence rate of cancer is increasing yearly,and chemotherapy-induced gastrointestinal mucosal injury has become a crucial factor affecting patients'therapeutic prognosis;however,there is currently a lack of effective therapeutic drugs to address this issue.There is thus an urgent need to establish more ideal animal models of chemotherapy-induced gastrointestinal mucosal injury,to support the exploration of its pathogenesis and the development of therapeutic drugs.This review considered relevant literature published during the period from 2019 to 2024,to provide a comprehensive summary and analysis from several perspectives,including the selection of experimental animals,chemotherapeutic drugs and modeling method,evaluation indicators,and practical applications.Furthermore,we highlight several existing issues with current models,including the lack of standardized modeling method,insufficient research on models with a tumor background,and inadequate exploration of novel cell death mechanisms.This collation of the literature also revealed the gradual emergence of traditional Chinese medicine as a research hotspot,with potential for the treatment of gastrointestinal mucosal injury.Further studies of effective medicines are warranted to identify interventional strategies for chemotherapy-induced gastrointestinal mucosal injury.关键词
化疗/胃肠黏膜损伤/动物模型/造模方法/发病机制Key words
Chemotherapy/gastrointestinal mucosal injury/animal model/modeling method/pathogenesis分类
生物科学引用本文复制引用
张以涵,黄珍祯,樊海艇,吴文斌,张超超,米金霞..化疗药物诱导的胃肠黏膜损伤动物模型研究进展[J].中国实验动物学报,2025,33(8):1235-1246,12.基金项目
上海中医药大学科技发展基金项目(23KFL007),上海中医药大学公共健康学院学科建设项目(GJ202201).Funded by Science and Technology Development Fund Project of Shanghai University of Traditional Chinese Medicine(23KFL007),Academic Discipline Construction Project for School of Public Health in Shanghai University of Traditional Chinese Medicine(GJ202201). （23KFL007）
