中国输血杂志2025，Vol.38Issue(9)：1177-1182,1247,7.DOI:10.13303/j.cjbt.issn.1004-549x.2025.09.009
围手术期输血与冠脉搭桥术后感染的相关性分析
Correlation between perioperative blood transfusion and postoperative infections following coronary artery bypass grafting
汤怡颖 1桑瑞瑞 2李杨 2戎瑞明 2聂怡宁 1魏仔媛 2周蓉2
作者信息
- 1. 上海市老年医学中心 输血科,上海 201100
- 2. 复旦大学附属中山医院 输血科,上海 200032
- 折叠
摘要
Abstract
Objective To explore the correlation between allogeneic red blood cell(RBC)transfusion and healthcare-associated infections(HAIs)in patients undergoing coronary artery bypass grafting(CABG)during the perioperative peri-od.Methods A single-center retrospective cohort of 1,170 patients undergoing isolated CABG was analyzed.Multivariable logistic regression and restricted cubic splines(RCS)were employed to explore the nonlinear association between periopera-tive RBC transfusion(from intraoperative period to 72 hours postoperatively)and HAIs.Results Among the 1,170 CABG patients,109 patients(9.2%)received RBC transfusion during the operation or within 3 days after the operation.The risk of HAIs in those who received≥4 units of RBCs during and within 3 days after the operation was 6.89 times higher than that in the non-transfusion group(95%CI:3.65-17.20).Furthermore,there was a nonlinear threshold effect between the blood transfusion volume and postoperative HAIs(inflection point:7.8 units).When the transfusion volume was≤7.8 u-nits,the risk of HAIs increased by 61%for each additional unit transfused(OR=1.61,95%CI:1.21-2.15).Beyond this threshold,no statistically significant association was observed(P=0.289).Conclusion Perioperative RBC transfusion in CABG patients is associated with an increased incidence of HAIs.The perioperative blood transfusion volume has a curvilinear relationship with the risk of postoperative HAIs.When the blood transfusion volume is≤7.8 units,the blood transfusion vol-ume has a dose-dependent relationship with postoperative infection,with higher blood transfusion volumes correlating with greater postoperative infection risk.When the blood transfusion volume is＞7.8 units,the relationship between the two is not statistically significant.The preventive effect of reducing RBC transfusion on HAIs requires further validation in the future.关键词
CABG/输血量/术后HAIKey words
CABG/blood transfusion volume/postoperative HAI分类
医药卫生引用本文复制引用
汤怡颖,桑瑞瑞,李杨,戎瑞明,聂怡宁,魏仔媛,周蓉..围手术期输血与冠脉搭桥术后感染的相关性分析[J].中国输血杂志,2025,38(9):1177-1182,1247,7.
