中国医学前沿杂志（电子版）2025，Vol.17Issue(7)：前插1,1-14,15.DOI:10.12037/YXQY.2025.07-01
肠菌移植应用于肿瘤治疗中国专家共识(2025年版)
Chinese expert consensus on application of fecal microbiota transplantation in cancer therapy(2025 edition)
中国抗癌协会肿瘤与微生态专业委员会 1湖北省免疫学会肿瘤与微生态专业委员会 1郭智 2王强3
作者信息
- 2. 深圳大学附属南山医院血液内科||深圳市血液中心||中国抗癌协会血液肿瘤整合康复专业委员会||中国抗癌协会肿瘤与微生态专业委员会||中华中医药学会免疫学分会||中国抗癌协会肿瘤血液病学专业委员会||中国抗癌协会感染性肿瘤专业委员会||中国抗癌协会肿瘤整体评估专业委员会||中国中西医结合学会干细胞与再生医学专业委员会||广东省预防医学会血液肿瘤防治专业委员会
- 3. 武汉科技大学医学部||中国抗癌协会肿瘤与微生态专业委员会||中华中医药学会免疫学分会||湖北省免疫学会||武汉免疫学会||湖北省免疫学会肿瘤微生态专业委员会||科普与教育专业委员会||湖北省艾滋病防治协会||武汉市预防医学会性病艾滋病专业委员会
- 折叠
摘要
Abstract
Fecal microbiota transplantation(FMT),also known as intestinal microbiota transplantation,has recently garnered increasing attention for its potential in cancer treatment.FMT demonstrates significant clinical benefits through gut microbiota reconstruction,including ameliorating intestinal dysbiosis after hematopoietic stem cell transplantation,reducing antibiotic resistance gene colonization,and exhibiting therapeutic potential for Clostridium difficile infection and graft-versus-host disease.Clinical evidence indicates that FMT significantly enhances gut microbiota diversity in cancer patients and potentiates anti-tumor efficacy when combined with immune checkpoint inhibitors,although the underlying mechanisms require further elucidation.Currently,clinical studies on FMT have significant limitations,particularly the paucity of high-quality double-blind randomized controlled trials(RCTs).Standardization of critical procedures,including donor screening protocols and dosage determination,remains inconsistent,significantly impacting the evidence hierarchy and clinical implementation.This expert consensus,based on evidence-based medicine and clinical practice,systematically evaluates the pivotal role and limitations of FMT in cancer treatment.The document presents 18 specific recommendations encompassing FMT applications in cancer treatment-related complications and combination therapies,emphasizing the need of protocol optimization based on individualized treatment principles.关键词
肠菌移植/造血干细胞移植/移植物抗宿主病/免疫治疗/专家共识Key words
Fecal microbiota transplantation/Hematopoietic stem cell transplantation/Graft-versus-host disease/Immunotherapy/Expert consensus引用本文复制引用
中国抗癌协会肿瘤与微生态专业委员会,湖北省免疫学会肿瘤与微生态专业委员会,郭智,王强..肠菌移植应用于肿瘤治疗中国专家共识(2025年版)[J].中国医学前沿杂志（电子版）,2025,17(7):前插1,1-14,15.
