中国中西医结合影像学杂志2025，Vol.23Issue(5)：640-646,7.DOI:10.3969/j.issn.1672-0512.2025.05.021
多b值DWI影像组学特征稳定性、可重复性及其对肝硬化的诊断效能
The stability,repeatability and diagnostic value of multi-b-value DWI radiomics features in liver cirrhosis
杨晓 1孟瑜 2万振法 2钱绍文 1孙亚明2
作者信息
- 1. 中国人民解放军联勤保障部队第九六〇医院放射诊断科,山东 济南 250031
- 2. 济南市第四人民医院放射科,山东 济南 250031
- 折叠
摘要
Abstract
Objective:To evaluate the stability,repeatability and diagnostic value of multi-b-value DWI radiomics features in liver cirrhosis.Methods:DWI data sets with multi-b-value of 126 cirrhosis patients in the liver cirrhosis group and 102 healthy volunteers in the control group were collected.Then,90 radiomics features were extracted from DWI images.The variation was evaluated by the percentage coefficient of variation(%COV),and the concordance correlation coefficient(CCC)was applied to assess the repeatability of DWI images.The features with the low variability and high repeatability across different b-values and patients were obtained.Another 53 liver cirrhosis patients and 53 healthy controls were collected as the external validation cohort for evaluate the diagnostic efficiency of radiomics features for liver cirrhosis.ROC curves were used to evaluate the diagnostic efficiency of radiomics features for liver cirrhosis.Results:Twenty-six radiomic features had low variation(%COV<20%)with multi-b-value and different patients.Thirteen features,such as GLRLM-RLNUN,GLCM-J.Entropy,between the liver cirrhosis group and the control group were statistically significantly different(all P<0.05).The radiomics features with higher repeatability were extracted from DWI image with neighbor b values.In the external validation cohort,GLRLM-RLNUN,GLDM-DNUN,GLCM-J.Entropy,GLCM-SumEntropy,IH-Entropy had the AUCs of 0.924,0.967,0.865,0.891,and 0.887,respectively.Conclusions:There are varying degrees of variation in radiomic features extracted from multi-b-value DWI images.The features derived from nearby b-value DWI have higher repeatibility.GLRLM-RLNUN,GLCM-J.Entropy,GLCM-SumEntropy,IH-Entropy and GLDM-DNUN can be served as non-invasive biomarkers for diagnosis of liver cirrhosis.关键词
肝硬化/影像组学/弥散加权成像/磁共振成像Key words
Liver cirrhosis/Radiomics/Diffusion weighted imaging/Magnetic resonance imaging引用本文复制引用
杨晓,孟瑜,万振法,钱绍文,孙亚明..多b值DWI影像组学特征稳定性、可重复性及其对肝硬化的诊断效能[J].中国中西医结合影像学杂志,2025,23(5):640-646,7.
