中国中药杂志2025，Vol.50Issue(15)：4238-4247,10.DOI:10.19540/j.cnki.cjcmm.20250428.101
化石类矿物药生龙骨、煅龙骨偏光显微物相鉴定及其健康风险评估
Polarized light microscopic mineral phase authentication and health risk assessment of raw and calcined fossil mineral Chinese medicinal material Draconis Os
摘要
Abstract
This study aims to investigate the polarized microscopic mineral phase characteristics,inorganic element content,and potential health risks associated with the intake of raw and calcined fossil mineral Chinese medicinal material Draconis Os.Microscopy was employed to observe the mineralogical characteristics of Draconis Os and compare the microscopic features and phase composition of raw and calcined Draconis Os under monochromatic and orthogonal polarized light.Inductively coupled plasma mass spectrometry(ICP-MS)was employed to determine the content of 30 inorganic elements.Health risk assessment was conducted by calculating the single pollution index(Pi),average daily intake of elements for adults(ADI),target hazard quotient(THQ),non-carcinogenic assessment method-hazard quotient(HQ),and the carcinogenic risk of elements(CR).The results indicated that under monochromatic polarized light,the Draconis Os powder sections exhibited light gray-brown to gray-brown irregular fragments,some with undulating textures that were slightly curved.Under crossed polarized light,they appeared dark gray,grayish-white,and yellowish-white.Clear apatite was visible in the ground sections of Draconis Os under crossed polarized light.Pi results indicated that Draconis Os samples were free from contamination and were of good quality.According to the maximum allowable limits of heavy metals stipulated in ISO Traditional Chinese Medicine:Determination of heavy metals in herbal medicines used in Traditional Chinese Medicine,ADI,THQ,HQ,and CR were taken as assessment indicators.Only the THQ value for As(arsenic)in raw Draconis Os was greater than 1,while the THQ values for other heavy metal elements in the Draconis Os samples were all less than 1.The study demonstrates that the primary mineral phase of raw and calcined Draconis Os is apatite,with some samples co-existing with calcite,which can serve as one of the means for quality control of Draconis Os.The elemental analysis results from ICP-MS provide scientific evidence for the safety assessment of Draconis Os,indicating that Draconis Os is safe in clinical application.关键词
矿物药/龙骨/煅龙骨/显微特征/ICP-MS/磷灰石/健康风险评估Key words
mineral Chinese medicinal materials/Draconis Os/calcined Draconis Os/microscopic characteristics/ICP-MS/apa-tite/healthy risk assessment引用本文复制引用
潘艳琼,刘政,郑丽文,张颖,周柳,钱喜龙,房方,吴骁,刘圣金..化石类矿物药生龙骨、煅龙骨偏光显微物相鉴定及其健康风险评估[J].中国中药杂志,2025,50(15):4238-4247,10.基金项目
江苏省高等学校基础科学(自然科学)研究重大项目(24KJA360006) （自然科学）
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023083) （zyyzdxk-2023083）
教育部科技委战略研究项目(2021) （2021）
全国第四次中药资源普查矿物药资源普查项目(GZY-KJS-2018-004) （GZY-KJS-2018-004）
中国中医科学院项目(20220088) （20220088）
