局解手术学杂志2025，Vol.34Issue(9)：772-775,4.DOI:10.11659/jjssx.05E024089
不同浓度辛伐他汀对大鼠坐骨神经损伤后再生作用的研究
Study on the mechanism of different concentrations of simvastatin on regeneration of sciatic nerve injury in rats
摘要
Abstract
Objective To explore the effects of different concentrations of simvastatin on nerve regeneration after sciatic nerve injury.Methods Rats were randomly divided into the normal group,the control group,the low-dose group and the high-dose group,with 3 rats in each group.Except for the normal group,adult rat sciatic nerve crush injury models were established in the other groups.Rats in the normal group and the control group were orally administered with water,while those in the low-dose group and high-dose group were orally administered with 98%simvastatin at dosages of 4 mg/mL and 40 mg/mL,respectively.The sciatic nerve regeneration in rats was evaluated by sciatic function index(SFI),HE staining,luxol fast blue(LFB)staining and immunofluorescence staining,etc.Results The SFI of rats in the high-dose group 7 days and 14 days after surgery were higher than those in the control group(P<0.05);there was no significant difference in SFI of rats between the low-dose group and the control group 7 days and 14 days after surgery(P>0.05).HE staining and LFB staining results showed that compared with the control group,the number of neurons of rats in the high-dose group increased,the nerve fibers and myelin were clearer and denser,and the nerve function was significantly restored;while no significant improvement was observed in the sciatic nerve of rats in the low-dose group.The immunofluorescence staining results showed that compared with the control group,the immunofluorescence intensity in the high-dose group increased,while that in the low-dose group decreased,the differences were statistically significant(P<0.05).Conclusion High-dose simvastatin can promote peripheral nerve regeneration by regulating the expression of M2 macrophages.关键词
辛伐他汀/坐骨神经/再生/大鼠Key words
simvastatin/sciatic nerve/regeneration/rat分类
医药卫生引用本文复制引用
李云虎,曹峻玮,李晨,张靖雨,顿爱社,王洪宾..不同浓度辛伐他汀对大鼠坐骨神经损伤后再生作用的研究[J].局解手术学杂志,2025,34(9):772-775,4.基金项目
2022年本科生研究计划(SRTP)暨大学生创新创业训练计划项目(2022104391561) （SRTP）
2023年泰安市科技创新发展项目(政策引导类)(2023NS245) （政策引导类）
