中国医药科学2025，Vol.15Issue(16)：42-47,6.DOI:10.20116/j.issn2095-0616.2025.16.08
NLRP3炎症小体在消化系统疾病中的作用和治疗研究现状
Progress in the role and treatment of NLRP 3 inflammasome in digestive diseases
程柳 1向永奎 1宛杰 2陈攀2
作者信息
- 1. 江西中医药大学研究生院,江西 南昌 330006
- 2. 湖北省黄梅县中医院康复科,湖北黄梅 438000
- 折叠
摘要
Abstract
The NOD-like receptor protein 3(NLRP3)inflammasome is typically composed of the NLRP3 protein,the apoptosis-associated speck-like protein containing a CARD(ASC),and caspase-1.The activation of this complex is closely related to the inflammatory processes in the digestive system.In digestive system diseases,abnormal activation of the NLRP3 inflammasome can lead to a range of detrimental effects.The author provides a comprehensive review of the activation process of the NLRP3 inflammasome in the pathogenesis of digestive system diseases,including both clinical and preclinical studies.This article discusses the regulatory mechanisms of NLRP3 inflammasome activation and its applications and relationships in digestive system diseases in recent years,aiming to offer new therapeutic insights and target directions for the treatment of clinical digestive system diseases.关键词
NOD样受体热蛋白结构域相关蛋白3炎症小体/消化系统疾病/炎症/作用机制Key words
NOD-like receptor thermal protein domain associated protein 3 inflammasome/Digestive system diseases/Inflammation/Mechanism of action分类
医药卫生引用本文复制引用
程柳,向永奎,宛杰,陈攀..NLRP3炎症小体在消化系统疾病中的作用和治疗研究现状[J].中国医药科学,2025,15(16):42-47,6.
