中国中药杂志2025，Vol.50Issue(16)：4407-4414,8.DOI:10.19540/j.cnki.cjcmm.20250417.601
从调控昼夜节律稳态角度探讨中药抗肝纤维化潜在作用机制
Mechanism of traditional Chinese medicine treatment of hepatic fibrosis by restoring circadian rhythms
摘要
Abstract
Hepatic fibrosis is a key pathological process in the development of chronic liver disease to cirrhosis,and its core mechanism involves the activation of hepatic stellate cells(HSC)and abnormal deposition of extracellular matrix(ECM).Although existing treatments,such as antiviral drugs,can delay disease progression,they have the problem of single therapeutic targets and cannot reverse fibrosis.Accordingly,multidimensional intervention strategies are urgently needed.Recent studies have shown that circadian rhythm disorders aggravate hepatic fibrosis by regulating metabolism,immunity,and inflammation.Traditional Chinese medicine(TCM)plays a unique role in restoring the circadian clock via multi-target and holistic regulation.This paper establishes a three-dimensional network by systematically integrating biological clock,metabolism,and immunity for the first time to elucidate the scientific connotation of the theory of time-concerned treatment of TCM,and proposes a new strategy for the development of time-targeted compound prescriptions,providing innovative ideas for the treatment of hepatic fibrosis.关键词
肝纤维化/昼夜节律/中药Key words
hepatic fibrosis/circadian rhythm/traditional Chinese medicine引用本文复制引用
张梦茹,江若楠,熊舒华,吴红雁,孔德松,陈利..从调控昼夜节律稳态角度探讨中药抗肝纤维化潜在作用机制[J].中国中药杂志,2025,50(16):4407-4414,8.基金项目
2023年度江苏省中医药科技发展计划青年人才项目(QN202304) （QN202304）
南京中医药大学自然科学基金项目(XZR2023012) （XZR2023012）
