中国中药杂志2025，Vol.50Issue(16)：4415-4424,10.DOI:10.19540/j.cnki.cjcmm.20250506.501
基于免疫疗法探讨中医药治疗非小细胞肺癌的研究进展
Research progress on treatment of non-small cell lung cancer with traditional Chinese medicine based on immunotherapy
摘要
Abstract
Non-small cell lung cancer(NSCLC)is the most common type of lung cancer worldwide,accounting for approximately 80％-85％of all lung cancer cases.Despite the clinical benefits of traditional treatments such as surgery,chemotherapy,and radiotherapy,challenges such as the high rate of postoperative recurrence and resistance of some patients to chemotherapy and targeted therapies limit their effectiveness,necessitating the exploration of more effective treatment options.In recent years,immunotherapy,especially immune checkpoint inhibitors(ICIs),has revolutionized NSCLC treatment and significantly improved the survival prognosis of some patients.However,the efficacy of immunotherapy is limited by tumor immune escape,drug resistance,and immune-related adverse events(irAEs),which have not been effectively addressed.Traditional Chinese medicine(TCM),as a traditional therapeutic approach,has shown unique advantages in NSCLC treatment,with studies indicating its ability to enhance immune responses,regulate immune checkpoints,and improve the tumor microenvironment(TME),thus boosting the efficacy of immunotherapy.Additionally,the multi-target and multi-pathway effects of TCM help mitigate the side effects of immunotherapy,further improving efficacy and safety.This review summarizes the latest research progress of TCM in NSCLC immunotherapy,focusing on the research results of TCM in enhancing the effect of immunotherapy by regulating immune cells,optimizing the immune microenvironment,and being applied with ICIs,etc.The latest research progress of TCM in alleviating irAEs is also elucidated.The aim is to provide theoretical support for the clinical application of TCM in the prevention and treatment of NSCLC and the research and development of new drugs and promote the optimization and development of combined immunotherapy and TCM treatment models.关键词
非小细胞肺癌/中医药/免疫治疗/研究进展Key words
non-small cell lung cancer/traditional Chinese medicine/immunotherapy/research progress引用本文复制引用
赵莹莹,卢子遇,李生龙,吴勉华..基于免疫疗法探讨中医药治疗非小细胞肺癌的研究进展[J].中国中药杂志,2025,50(16):4415-4424,10.基金项目
第二届全国名中医工作室项目 （）
吴勉华全国名老中医药专家传承工作室项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
国家中医药管理局第七批全国老中医药专家学术经验继承工作项目(国中医药人教函[2022]76号) （国中医药人教函[2022]76号）
吴勉华江苏省名老中医药专家传承工作室项目(苏中医科教[2021]7号) （苏中医科教[2021]7号）
国家中医药管理局中医药传承与创新"百千万"人才工程项目(岐黄工程)岐黄学者项目(国中医药人教函[2018]284号) （岐黄工程）
国家中医临床研究基地(江苏省中医院)开放课题(JD2023SZ11) （江苏省中医院）
