中国中药杂志2025，Vol.50Issue(16)：4425-4436,12.DOI:10.19540/j.cnki.cjcmm.20250423.501
中药抑制细胞焦亡治疗脓毒症急性肺损伤的研究进展与探析
Research progress and exploration of traditional Chinese medicine in treatment of sepsis-acute lung injury by inhibiting pyroptosis
摘要
Abstract
Sepsis is a systemic inflammatory response caused by severe infection or trauma,and is one of the common causes of acute lung injury(ALI)and acute respiratory distress syndrome(ARDS).Sepsis-acute lung injury(SALI)is a critical clinical condition with high morbidity and mortality.Its pathogenesis is complex and not yet fully understood,and there is currently a lack of targeted and effective treatment options.Pyroptosis,a novel form of programmed cell death,plays a key role in the pathological process of SALI by activating inflammasomes and releasing inflammatory factors,making it a potential therapeutic target.In recent years,the role of traditional Chinese medicine(TCM)in regulating signaling pathways related to pyroptosis through multi-components and multi-targets has attracted increasing attention.TCM may intervene in pyroptosis by inhibiting the activation of NLRP3 inflammasomes and regulating the expression of Caspase family proteins,thus alleviating inflammatory damage in lung tissues.This paper systematically reviews the molecular regulatory network of pyroptosis in SALI and explores the potential mechanisms and research progress on TCM intervention in cellular pyroptosis.The aim is to provide new ideas and theoretical support for basic research and clinical treatment strategies of TCM in SALI.关键词
中药/脓毒症/急性肺损伤/细胞焦亡/分子机制Key words
traditional Chinese medicine/sepsis/acute lung injury/pyroptosis/molecular mechanism引用本文复制引用
吴文玉,曾瑞峰,李俊,李诺然,王凯,焦欣,蓝婉宁,徐运升,王林,林景楠,陈瑞..中药抑制细胞焦亡治疗脓毒症急性肺损伤的研究进展与探析[J].中国中药杂志,2025,50(16):4425-4436,12.基金项目
国家自然科学基金项目(82204936,82474409) （82204936,82474409）
广东省名中医传承工作室建设项目(粤中医办函[2023]108号) （粤中医办函[2023]108号）
中医药广东省实验室科技研发培植项目(HQL2024PZ004) （HQL2024PZ004）
广州市科技计划基础与应用基础研究项目(2023A04J0476) （2023A04J0476）
广东省中医急症研究重点实验室专项(2023B1212060062,YN2023JZ18,YN2023JZ19) （2023B1212060062,YN2023JZ18,YN2023JZ19）
广东省中医院中医药科学技术研究专项(YN2023MS42) （YN2023MS42）
广东省中医药科研项目(20231169,20251124) （20231169,20251124）
广东省自然科学基金项目(2021A1515012224,2024A1515012160) （2021A1515012224,2024A1515012160）
国家中医药传承创新中心科研专项(2022QN24,2022QN27) （2022QN24,2022QN27）
广东省医学科学技术研究基金项目(B2023051) （B2023051）
