中国医科大学学报2025，Vol.54Issue(9)：786-790,5.DOI:10.12007/j.issn.0258-4646.2025.09.004
衰减斑块患者PCI术前冠状动脉内注射腺苷及硝普钠的疗效分析
Efficacy of intracoronary injection of adenosine and sodium nitroprusside before PCI in patients with attenuated plaques
摘要
Abstract
Objective To investigate the efficacy of preprocedural intracoronary injections of adenosine and sodium nitroprusside in patients with intravascular ultrasound-attenuated plaques(AP).Methods In total,200 patients with AP detected using intravascular ultrasound(IVUS)at Shijiazhuang People's Hospital from January 1,2022,to January 1,2024,were selected and randomly divided into conventional treatment and pretreatment groups,with 100 patients in each group.The conventional treatment group underwent standard percutaneous coronary intervention(PCI)procedures,whereas the pretreatment group underwent intracoronary injection of sodium nitro-prusside and adenosine through a guiding catheter prior to PCI.The observation parameters included intraoperative no-reflow(NR)inci-dence,post-PCI TIMI myocardial perfusion frame count(TMPFC),perioperative myocardial infarction(PMN),and 6-month major adverse cardiac and cerebrovascular events(MACCE).Results The pretreatment group exhibited a significantly lower intraoperative NR inci-dence,reduced postoperative TMPFC,and attenuated PMN severity than the conventional treatment group(P＜0.05).Conclusion Pre-procedural intracoronary administration of adenosine and sodium nitroprusside through a guiding catheter can effectively reduce PCI-re-lated NR occurrence,improve post-PCI TMPFC,and mitigate PMN in patients with AP,although no significant improvement in MACCE incidence can be observed at the 6-month follow-up.关键词
衰减斑块/腺苷/硝普钠/经皮冠脉介入术/无复流Key words
attenuated plaque/adenosine/sodium nitroprusside/percutaneous coronary intervention/no-reflow分类
医药卫生引用本文复制引用
王硕,李柳,高志超,耿红,徐雷,武如冰..衰减斑块患者PCI术前冠状动脉内注射腺苷及硝普钠的疗效分析[J].中国医科大学学报,2025,54(9):786-790,5.基金项目
河北省卫生健康委员会医学科学研究课题(20240119) （20240119）
