中国中药杂志2025，Vol.50Issue(16)：4437-4450,14.DOI:10.19540/j.cnki.cjcmm.20250512.502
中医药治疗糖皮质激素性骨质疏松的理论探讨及研究进展
Theoretical discussion and research progress on treatment of glucocorticoid-induced osteoporosis with traditional Chinese medicine
摘要
Abstract
Glucocorticoid-induced osteoporosis(GIOP)is a serious metabolic bone disease caused by long-term application of glucocorticoids(GCs).Traditional Chinese medicine(TCM)has unique advantages in improving bone microstructure and antagonizing hormone toxicity.This paper systematically reviews the theoretical research,clinical application,and basic research progress of TCM intervention in GIOP.In terms of theoretical research,the theory of"kidney governing bone and generating marrow"indicates that the kidney is closely related to bone development,revealing that core pathogenesis of GIOP is Yin-Yang disharmony,which can be discussed using the theories of"Yin fire","ministerial fire",and"Yang pathogen damaging Yin".Thus,regulating Yin and Yang is the basic principle to treat GIOP.In terms of clinical application,effective empirical prescriptions(such as Bushen Zhuanggu Decoction,Bushen Jiangu Decoction,and Zibu Ganshen Formula)and Chinese patent medicines(Gushukang Capsules,Hugu Capsules,Xianling Gubao Capsules,etc.)can effectively increase bone mineral density(BMD)and improve calcium and phosphorus metabolism.The combination of traditional Chinese and western medicine can reduce the risk of fracture and play an anti-GIOP role.In terms of basic research,it has been clarified that active ingredients of TCM(such as fraxetin,ginsenoside Rg1,and salidroside)reduce bone loss and promote bone formation by inhibiting oxidative stress,ferroptosis,and other pathways,effectively improving bone homeostasis.Additionally,classical prescriptions(Modified Yiguan Decoction,Modified Qing'e Pills,Zuogui Pills,etc.)and Chinese patent medicines(Gushukang Granules,Lurong Jiangu Dropping Pills,Gubao Capsules,etc.)can improve bone marrow microcirculation,promote osteoblast differentiation,and inhibit bone cell apoptosis through multiple pathways,multiple targets,and multiple mechanisms.Through the above three aspects,the TCM research status on GIOP is elucidated in the expectation of providing reference for its diagnosis and treatment using traditional Chinese and western medicine treatment programs.关键词
糖皮质激素性骨质疏松/中医理论/临床应用/基础研究/研究进展Key words
glucocorticoid-induced osteoporosis/traditional Chinese medicine theory/clinical application/basic research/research progress引用本文复制引用
徐婷婷,丁樱,张霞,王龙,徐闪闪,宋纯东,翟文生,任献青..中医药治疗糖皮质激素性骨质疏松的理论探讨及研究进展[J].中国中药杂志,2025,50(16):4437-4450,14.基金项目
第四届国医大师传承工作室项目(国中医药办人教函[2022]245号) （国中医药办人教函[2022]245号）
国家自然科学基金项目(82474568) （82474568）
2022年度河南省健康中青年学科带头人培养项目(豫卫人[2022]26号) （豫卫人[2022]26号）
河南省中医学"双一流"创建科学研究专项(HSRP-DFCTCM-2023-2-10,HSRP-DFCTCM-2023-3-15) （HSRP-DFCTCM-2023-2-10,HSRP-DFCTCM-2023-3-15）
