中国中药杂志2025，Vol.50Issue(16)：4451-4470,20.DOI:10.19540/j.cnki.cjcmm.20250331.303
人参皂苷改善急性肺损伤的分子机制研究进展
Research progress on molecular mechanisms of ginsenosides in alleviating acute lung injury
摘要
Abstract
Acute lung injury(ALI)is a critical clinical condition primarily characterized by refractory hypoxemia and infiltration of inflammatory cells in lung tissue,which can progress into a more severe form known as acute respiratory distress syndrome(ARDS).Immune cells and inflammatory cytokines play important roles in the progression of the disease.Due to its unclear pathogenesis and the lack of effective clinical treatments,ALI is associated with a high mortality rate and severely affects patients' quality of life,making the search for effective therapeutic agents particularly urgent.Ginseng Radix et Rhizoma,the dried root of the perennial herb Panax ginseng from the Araliaceae family,contains active ingredients such as saponins and polysaccharides,which possess various pharmacological effects including anti-tumor activity,immune regulation,and metabolic modulation.In recent years,studies have shown that ginsenosides exhibit notable effects in reducing inflammation,ameliorating epithelial and endothelial cell injury,and providing anticoagulant action,indicating their comprehensive role in alleviating lung injury.This review summarizes the pathogenesis of ALI and the molecular mechanisms through which ginsenosides act at different stages of ALI development.The aim is to provide a scientific reference for the development of ginsenoside-based drugs targeting ALI,as well as a theoretical basis for the clinical application of Ginseng Radix et Rhizoma in the treatment of ALI.关键词
急性肺损伤/人参/人参皂苷/分子机制/抗炎Key words
acute lung injury/Ginseng Radix et Rhizoma/ginsenosides/molecular mechanisms/anti-inflammation引用本文复制引用
赵菡扬,丁丽丽,王汛江,薛琼雯,徐宝莲,王旭,赖树生,陈明,杨莉,王峥涛..人参皂苷改善急性肺损伤的分子机制研究进展[J].中国中药杂志,2025,50(16):4451-4470,20.基金项目
国家自然科学基金区域创新发展联合研究项目(U24A20792) （U24A20792）
国家自然科学基金重点项目(82130115) （82130115）
