中华临床免疫和变态反应杂志2025，Vol.19Issue(4)：252-257,6.DOI:10.3969/j.issn.1673-8705.2025.04.008
免疫检查点抑制剂相关不良反应生物标志物的研究进展
Research advances in biomarkers for checkpoint inhibitor immune-related adverse e-vents
摘要
Abstract
The application of immune check-point inhibitors(ICIs)has significantly improved the sur-vival rate of cancer patients.However,more than half of the patients experience immune-related adverse events(irAEs),which may lead to treatment discontinuation and even life-threatening situations.Identifying predic-tive biomarkers of irAEs is essential to enhance the survival and quality of life of cancer patients undergoing ICIs therapy.This review aimed to summarize the current advances in biomarkers for predicting irAEs,providing guidance for clinical decision-making.关键词
免疫检查点抑制剂/免疫相关不良反应/生物标志物Key words
immune checkpoint inhibitors/immune-related adverse events/biomarkers引用本文复制引用
陈佳娜,徐佳琪,姜旭,杨华夏..免疫检查点抑制剂相关不良反应生物标志物的研究进展[J].中华临床免疫和变态反应杂志,2025,19(4):252-257,6.基金项目
中国医学科学院医学与健康科技创新工程项目(2023-I2M-C&T-B-041) CAMS Innovation Fund for Medical Sciences(CIFMS,2023-I2M-C&T-B-041) （2023-I2M-C&T-B-041）
