中华临床免疫和变态反应杂志2025，Vol.19Issue(4)：268-273,6.DOI:10.3969/j.issn.1673-8705.2025.04.010
cGAS-STING信号通路在类风湿关节炎中的研究进展
Research progress of cGAS-STING signaling pathway in rheumatoid arthritis
摘要
Abstract
Rheumatoid arthritis(RA)is a chronic inflammatory disease caused by abnormalities in the immune system,characterized by joint pain,swelling,and dysfunction.In recent years,the cGAS-STING signaling pathway has received extensive attention as an important mechanism of intracellular immune re-sponse.cGAS(circular GMP-AMP synthetase)activates STING(stimulation of interferon gene)proteins by recognizing intracellular DNA and synthesizing cGAMP,thereby initiating downstream antiviral immune respon-ses and inflammatory responses.Studies have found that the cGAS-STING signaling pathway not only plays a key role in the defense of pathogenic infection,but also plays an important role in the occurrence and development of autoimmune diseases such as RA.Based on this,the cGAS-STING pathway has become a potential therapeu-tic target for RA.Future studies need to further explore the specific mechanism of this pathway in RA and devel-op corresponding treatment strategies.关键词
cGAS-STING信号通路/类风湿关节炎/干扰素/免疫反应Key words
cGAS-STING signaling pathway/rheumatoid arthritis/IFN/immunoreaction引用本文复制引用
高琴,李佳茹,石慧..cGAS-STING信号通路在类风湿关节炎中的研究进展[J].中华临床免疫和变态反应杂志,2025,19(4):268-273,6.基金项目
内蒙古自治区自然科学一般联合基金项目(2025LHMS08078):航天医疗健康科技集团有限公司重点项目(2024YK11) （2025LHMS08078）
内蒙古自治区研究生科研创新项目(KC2024051S) （KC2024051S）
内蒙古医科大学联合项目(YKD2023LH025) （YKD2023LH025）
内蒙古医科大学重点实验室开放基金(2022NYFYSYS004) Natural Science Foundation of Inner Mongolia Autonomous Region(2025LHMS08078) （2022NYFYSYS004）
Science Foundation of AMHT(2024YK11) （2024YK11）
Inner Mongolia Autonomous Region Graduate Research and Innovation Project(KC2024051S) （KC2024051S）
Inner Mongolia Medical University Joint Project(YKD2023LH025) （YKD2023LH025）
Open Fund of Key Laboratories of Inner Mongolia Medical University(2022NYFYSYS004) （2022NYFYSYS004）
