中国医药科学2025，Vol.15Issue(16)：99-103,5.DOI:10.20116/j.issn2095-0616.2025.16.20
2型糖尿病患者血清同型半胱氨酸水平与肾小球滤过率的相关性研究
A correlative study on the levels of serum homocysteine and glomerular filtration rate in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To explore the correlation between the levels of serum homocysteine(HCY)and the estimated glomerular filtration rate(eGFR)in patients with type 2 diabetes mellitus(T2DM).Methods This study selected T2DM patients admitted to the Department of Endocrinology/Pediatric Endocrinology and Genetic Metabolism Department at Gansu Provincial Central Hospital between July 2022 and May 2023 as the research population.Clinical medical records were collected for retrospective analysis.Participants were divided into three groups according to the tertile levels of serum homocysteine:the low homocysteine group(HCY<10.33 μmol/L),the medium homocysteine group(10.33 μmol/L≤HCY<13.72 μmol/L),and the high homocysteine group(HCY≥13.72 μmol/L).Differences in glucose and lipid metabolism indices among groups were compared.Logistic regression analysis was used to investigate the correlation between Hcy and eGFR.Results In patients with T2DM,as the level of HCY increased,the age,the proportion of males,the proportion of those with a smoking history,and the proportion of those with a history of hypertension gradually increased,with statistically significant differences(P<0.05).The level of fasting C-peptide increased with the increase in serum HCY,showing a statistically significant difference(P<0.05).The levels of high-density lipoprotein cholesterol and e GFR decreased with the increase in serum HCY,with statistically significant differences(P<0.05).As the tertile level of HCY increased,the eGFR decreased,with values of(102.30[87.70,125.70]),(100.15[86.30,117.40]),and(94.25[78.75,114.75])ml/(min·1.73m2)respectively,and the difference was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that without adjusting for confounding factors,the eGFR in the high homocysteine group was significantly lower than that in the low homocysteine group(β=-0.15,95%CI:-0.23 to-0.07,P<0.001),suggesting that the eGFR in patients with high homocysteine was 13.9%lower on average than that in the low homocysteine group(e^[-0.15]-1).After adjusting for confounding factors of age and gender,the negative correlation in the high homocysteine group remained significant(β=-0.15,95%CI:-0.21 to-0.08,P<0.001).After further adjusting for confounding factors such as smoking,alcohol consumption,body mass index,high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol,the regression coefficient of the high homocysteine group was-0.12(95%CI:-0.19 to-0.06,P<0.001),indicating that the eGFR in the group with the highest HCY level was 11.3%lower than that in the low homocysteine group(e^[-0.12]-1).Conclusion There was a correlation between serum HCY levels and eGFR in T2DM patients,and an elevated HCY level was a risk factor for reduced eGFR.关键词
2型糖尿病/同型半胱氨酸水平/肾小球滤过率/相关性Key words
Type 2 diabetes mellitus/Homocysteine level/Estimated glomerular filtration rate/Correlation分类
医药卫生引用本文复制引用
傅娟,王艺嵘,侯红斌,孙波..2型糖尿病患者血清同型半胱氨酸水平与肾小球滤过率的相关性研究[J].中国医药科学,2025,15(16):99-103,5.基金项目
甘肃省自然科学基金(23JRRA1748). （23JRRA1748）
