中国医药科学2025，Vol.15Issue(16)：111-116,6.DOI:10.20116/j.issn2095-0616.2025.16.22
LARS人工韧带与自体腘绳肌肌腱重建膝关节前交叉韧带临床疗效比较的meta分析
A meta-analysis of clinical efficacy of knee anterior cruciate ligament reconstruction by arthroscopy between LARS artificial ligament and autologous hamstring tendon
摘要
Abstract
Objective This study comprehensively evaluates the effectiveness and safety of Ligament Advanced Reinforcement System(LARS)artificial ligament compared to autologous hamstring tendon reconstruction for anterior cruciate ligament(ACL)in aspects such as return to sports and recovery of knee joint function.Methods A comprehensive computer search was conducted in PubMed,Embase,The Cochrane Library,CNKI,VIP,and Wanfang databases to collect randomized controlled trials and clinical controlled studies comparing the clinical efficacy of LARS artificial ligament and autologous hamstring tendon reconstruction for ACL.The search period was from database inception to February 29,2024.The quality of the literature was assessed using the Cochrane Collaboration's risk of bias assessment tool for randomized controlled trials and the Newcastle-Ottawa scale(NOS)for case-control or prospective cohort studies.Data extraction was analyzed using RevMan 5.3 software.Results A total of 9 clinical studies were included,with a total sample size of 604 cases(260 cases in the LARS ligament group and 344 cases in the autologous popliteus tendon group).Meta-analysis showed that the Lysholm knee scoring scale(Lysholm)scores were higher in the LARS group than in the HT group at 6 months postoperatively,and the difference was statistically significant(SMD=6.18,95%CI[4.11,8.25],P<0.000 01).In the LARS group at 24 months postoperatively Lysholm score had no significant advantage over the HT group,and the difference was not statistically significant(SMD=0.67,95%CI[-0.95,2.28],P=0.42).The LARS group had a higher postoperative Tegner score at 6 months after surgery than the HT group,and the difference was statistically significant(MD=1.71,95%CI[1.36,2.05],P<0.000 01).Tegner scores were comparable to those of the HT group in the LARS group at 24 months postoperatively,and the difference was not statistically significant(MD=-0.02,and 95%CI[-0.21,0.16],P=0.80).The International Knee Documentation Committee Subjective Knee Form(IKDC)score was higher in the LARS group than in the HT group at 6 months postoperatively,and the difference was significant(SMD=4.04,95%CI[2.38,5.70],P<0.000 01).IKDC score at 24 months postoperatively in the LARS group was comparable to that of the HT group,and the difference was statistically significant.scores were comparable to those of the HT group,and the difference was not statistically significant(SMD=0.12,95%CI[-0.19,0.43],P=0.44).The LARS group had a smaller KT-1000 or KT-2000 at the final follow-up than that of the HT group,and had better postoperative knee stability,and the difference was statistically significant(SMD=-0.61,95%CI[-1.16,-0.05],P=0.03).The time to return to sports was shorter in the LARS group than in the HT group,and the difference was statistically significant(MD=-8.45,95%CI[-10.78,-6.13],P<0.000 01).The incidence of postoperative complications in the LARS group was lower than in the HT group,and the difference was statistically significant(OR=0.38,95%CI[0.19,0.73],P=0.004).Conclusion In terms of knee joint function scores(Lysholm score,Tegner score,IKDC score),the use of LARS artificial ligament for ACL reconstruction shows superior early postoperative efficacy(6 and 12 months)compared to autologous hamstring tendon.However,efficacy is comparable at 24 months postoperatively.LARS artificial ligament allows for earlier return to sports compared to autologous hamstring tendon.Additionally,for knee joint stability and The incidence of postoperative complications,LARS artificial ligament reconstruction for ACL is superior to autologous hamstring tendon.关键词
LARS人工韧带/自体腘绳肌腱/前交叉韧带重建/meta分析Key words
LARS artificial ligament/Autologous hamstring tendon/ACL reconstruction/meta-analysis分类
医药卫生引用本文复制引用
简虓,彭磊,郑伟,邹成成,王胜茹..LARS人工韧带与自体腘绳肌肌腱重建膝关节前交叉韧带临床疗效比较的meta分析[J].中国医药科学,2025,15(16):111-116,6.基金项目
河南省南阳市科技计划项目(KJGG123). （KJGG123）
