肿瘤防治研究2025，Vol.52Issue(9)：770-775,6.DOI:10.3971/j.issn.1000-8578.2025.25.0162
郑州地区女性宫颈HPV持续感染的流行病学研究
Persistent HPV Infection Among Women in Zhengzhou,China:A Prevalence Study
摘要
Abstract
Objective To analyze the status of persistent human papillomavirus(HPV)infection and the distribution of viral subtypes in the Zhengzhou region.Methods Clinical data of 55239 patients who underwent HPV-DNA genotyping tests from 2018 to 2024 were collected.On the basis of HPV follow-up results,patients were divided into three groups:849 cases of infection with the same HPV type,255 cases of persistent infection with different HPV types,and 857 cases of transient HPV infection.Results Among the 9232 initially-screened patients who were positive with HPV,the high-risk HPV(HR-HPV)positive rate was 84.6%(7813/9232),and predominant subtypes were HPV-16(20.8%),HPV-52(17.2%),and HPV-53(9.6%).The low-risk HPV(LR-HPV)positive rate was 15.4%(1419/9232),mainly HPV-81(28.1%)and HPV-42(27.0%).Among the 1961 follow-up cases,the rates of persistent and non-persistent infections with the same HPV type were 35.7%(701/1961)and 7.5%(148/1961),respectively.The rates of persistent and non-persistent infections with different HPV types were 10.9%(214/1961)and 2.1%(41/1961),respectively.Meanwhile,43.7%(857/1961)tested negative upon follow-up.Among the 701 cases of persistent infection with the same HPV type,HR-HPV accounted for 85.7%(601/701),and LR-HPV accounted for 14.3%(100/701).Among the 214 cases of persistent infection with different HPV types,89.7%(192/214)were high-risk transitions,and 10.3%(22/214)were low-risk transitions.Regardless of HPV types,HR-HPV was more likely to cause persistent infection than LR-HPV.In addition,over 60%of HR-HPV persistent infections resolved within 18 months,30%developed into persistent infections,and only 15%of patients had persistent infections that last more than 24 months.Conclusion Persistent HPV infections are predominantly high-risk types.Most patients clear the infection within 18 months,approximately 30%develop persistent infections,and about 15%of patients have persistent infections that last more than 24 months.However,the HR-HPV persistent infection rates across different age groups slightly differ.关键词
高危型人乳头瘤病毒/HPV持续感染/宫颈癌/宫颈上皮内病变Key words
High-risk human papillomavirus/Persistent HPV infection/Cervical cancer/Cervical intraepithelial lesions分类
医药卫生引用本文复制引用
段海霞,钱进,张瑶,任志敏,赵国红,洪钧言,李新敏..郑州地区女性宫颈HPV持续感染的流行病学研究[J].肿瘤防治研究,2025,52(9):770-775,6.基金项目
He'nan Provincial Key Research and Development Program in Medicine and Health Sciences(No.LHGJ20230765) （No.LHGJ20230765）
Zhengzhou City Foreign Experts Introduction Program(No.ZZG2S2023001) （No.ZZG2S2023001）
Zhengzhou City Science&Technology for Public Welfare Program(No.2023KJHM0004) （No.2023KJHM0004）
He'nan Provincial Science and Technology Development Plan Project in 2024(No.242102310161) 河南省医学科技攻关计划项目(LHGJ-20230765) （No.242102310161）
郑州市引进外国专家项目(ZZG2S2023001) （ZZG2S2023001）
郑州市科技惠民计划项目(2023KJHM0004) （2023KJHM0004）
河南省2024年科技发展计划项目(242102310161) （242102310161）
