转化医学杂志2025，Vol.14Issue(9)：37-41,5.DOI:10.3639/j.issn.2095-3097.2025.09.008
血尿酸轨迹与急性心力衰竭患者临床救治效果的关系队列研究
A Cohort Study on the Relationship between Serum Uric Acid Trajectory and Clinical Treatment Efficacy in Patients with Acute Heart Failure
摘要
Abstract
Objective To investigate the relationship between serum uric acid(SUA)trajectory and clinical treatment efficacy in patients with acute heart failure(AHF).Methods A total of 100 patients with AHF admitted to Anhui No.2 Provincial People's Hospital from February 2022 to February 2024 were selected,and all received standardized treatment.SUA data measured at different time points were collected,and SUA development trajectories were identified using latent class growth modeling.Patients were classified into a low SUA trajectory group(56 cases),a medium SUA trajectory group(32 cases),and a high SUA trajectory group(12 cases)based on SUA levels,and were further divided into an effective group(77 cases)and an ineffective group(23 cases)according to clinical treatment outcomes.Multivariable Logistic regression was used to analyze the influence of SUA trajectory on clinical treatment outcomes in AHF patients and to identify independent risk factors affecting clinical treatment outcomes.Results The SUA levels in 100 AHF patients at admission,14 days of treatment,end of treatment,and 3 months after treatment were(620.52±102.20)μmol/L,(415.50±82.55)μmol/L,(285.50±60.25)μmol/L,and(200.40±20.25)μmol/L,respectively,showing an overall decreasing trend(F=627.844,P<0.05).There were significant differences among the low,medium,and high SUA trajectory groups in cardiac function classification(class Ⅲ-Ⅳ),serum creatinine levels,and N-terminal pro-B-type natriuretic peptide levels(P<0.05).The inefficiency rates after treatment differed significantly among the low,medium,and high SUA trajectory groups(10.71%vs 31.25%vs 58.33%;Z=8.313,P<0.05).Multivariable Logistic regression analysis showed that cardiac function classification(class Ⅲ-Ⅳ),N-terminal pro-B-type natriuretic peptide,cardiac troponin I,non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio,SUA level,and high SUA trajectory were independent risk factors affecting clinical treatment outcomes in AHF patients(OR=1.722,95%CI:1.252-2.229,P<0.01;OR=1.863,95%CI:1.453-2.272,P<0.01;OR=1.893,95%CI:1.396-2.389,P<0.01;OR=1.900,95%CI:1.406-2.395,P<0.01;OR=1.853,95%CI:1.470-2.237,P<0.01;OR=1.835,95%CI:1.465-2.205,P<0.01).Conclusion There is population heterogeneity in SUA levels among AHF patients,and changes in SUA levels are associated with clinical treatment outcomes.关键词
急性心力衰竭/血尿酸轨迹/临床救治效果/队列研究Key words
acute heart failure/serum uric acid trajectory/clinical treatment efficacy/cohort study引用本文复制引用
许恩文,李雪奇,李世光,张庆斌,张瑞雷..血尿酸轨迹与急性心力衰竭患者临床救治效果的关系队列研究[J].转化医学杂志,2025,14(9):37-41,5.基金项目
安徽省高校自然科学研究项目(ZR2021B006) （ZR2021B006）
