中国药业2025，Vol.34Issue(18)：15-19,5.DOI:10.3969/j.issn.1006-4931.2025.18.004
某三甲医院糖尿病肾病患者降糖药使用现状的Apriori算法分析
Current Status and Association Analysis of Hypoglycemic Drugs Usage in Diabetic Nephropathy Patients in A Tertiary Grade A Hospital Based on the Apriori Algorithm
摘要
Abstract
Objective To provide reference for clinical rational application of hypoglycemic drugs in patients with diabetic nephropathy(DN).Methods The hospital electronic medical record system was used to retrieve the medical records of DN patients discharged from a tertiary hospital from January to August 2023 according to the medical orders.The patient's basic data,laboratory indicators and medication according to medical orders(2 010 d)were extracted.The medication was evaluated according to the estimated glomerular filtration rate(eGFR),and the use of hypoglycemic drugs during hospitalization was recorded.Based on the Apriori algorithm,the correlation between the combined application of hypoglycemic drugs was analyzed.Results A total of 197 patients were included,among which 135 cases were males and 62 cases were females,the age was(59.82±13.75)years,the body mass index was(25.09±3.26)kg/m2,there were 124 cases(62.94%)with overweight/obesity,and 140 cases(71.06%)with cardiovascular disease(hypertension).A total of 8 categories and 31 varieties of hypoglycemic drugs were used.The usage rate of insulin in patients with different eGFR was higher(≥77.78%).With the increase of eGFR,the number of hypoglycemic drugs used by patients gradually increased(10 → 31 varieties),and the usage rate of sodium-glucose cotransporter 2(SGLT2i)and biguanides gradually increased.The most common dual therapy was insulin+SGLT2i(support was 57.26%,confidence was 79.76%),and the triple therapy was SGLT2i+insulin+glucagon-like peptide-1 receptor agonists(GLP-1 RAs)(support was 26.63%,confidence was 76.84%).SGLT2i,insulin and GLP-1 RAs were strongly correlated.A total of 13 cases(6.54%)did not reduce or discontinue medications according to their eGFR levels.The involved drugs included Metformin Tablets,Sitagliptin Tablets,Saxagliptin Tablets,Liraglutide Injection,etc.Conclusion A large number of DN patients in this hospital are complicated with cardiovascular diseases,and hypoglycemic therapy is mainly based on combination medication.SGLT2i has become the most widely used choice in combination therapy due to their ability to bring cardiorenal benefits and reduce body weight in patients,which is basically consistent with the recommendations in clinical practice guidelines.Meanwhile,it is suggested that the dose of hypoglycemic drugs should be adjusted according to the level of eGFR,and strengthen the management of rational drug use.关键词
Apriori算法/糖尿病肾病/降糖药/关联分析Key words
Apriori algorithm/diabetic nephropathy/hypoglycemic drugs/Correlation analysis分类
医药卫生引用本文复制引用
雷婷,程云生,于刚,贾犇黎,王媛媛..某三甲医院糖尿病肾病患者降糖药使用现状的Apriori算法分析[J].中国药业,2025,34(18):15-19,5.基金项目
安徽省卫生健康科研项目[AHWJ2023BAc10009]. （）
